Preventing the formation of secretory structures that promote scarring in the kidney could offer new therapeutic options for a disease that affects millions of people worldwide.

Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.

A link between anti-inflammatory drugs such as ibuprofen and C. diff infection suggests caution against overusing such drugs in patients at high risk for infection.

DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.

Vanderbilt investigators are defining the genetic programs that control the development of pancreatic beta cells — studies that could inform new cellular or regenerative therapies for diabetes.

A greater understanding of the mechanisms and cell types involved in returning adipose (fatty) tissue to the lean state may lead to more effective treatments for obesity.

A compound that activates a virus-sensing receptor has potent therapeutic effects in a mouse model of breast cancer.