Aliquots - Research Briefs

July 25, 2017

Altered metabolism and disease

Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

By VUMC News and Communications
iStock Photo
July 24, 2017

How Epo action is ‘enhanced’

The hormone erythropoietin (Epo) controls red blood cell production and synthetic forms of Epo treat multiple disorders. New Vanderbilt research details how Epo works.

By Bill Snyder
July 21, 2017

Probing the genetics of autoimmunity

Vanderbilt researchers have found that non-coding regions of the genome appear to contribute to the risk of autoimmune diseases and may represent attractive therapeutic targets.

By Leigh MacMillan
July 20, 2017

Drivers of breast cancer metastasis

Signaling through a complex of proteins called mTORC2 plays a role in breast cancer migration, invasion and metastasis, Vanderbilt researchers reported.

By Leigh MacMillan
bacteria microbiome
July 5, 2017

Bile acids, microbiota and colon cancer

Bile acids produced by a western diet alter the composition of the gut microbiota and promote intestinal carcinogenesis.

By Leigh MacMillan
July 3, 2017

NOTCH1 role in heart development

The identification of a genetic culprit for hypoplastic left heart syndrome could lead to new treatments for the condition.

By VUMC News and Communications
June 30, 2017

Cytokine linked to blindness

A signaling molecule called interleukin-6 may be a therapeutic target to prevent vision loss or nerve degeneration in glaucoma, Vanderbilt researchers have discovered.
By VUMC News and Communications
June 29, 2017

Genetics of lung cancer survival

Vanderbilt investigators have conducted a first-of-its-kind genome-wide association study of lung cancer survival in African-Americans.
By Sanjay Mishra
June 19, 2017

STINGing combination for cancer

A novel immunotherapy combination induced remarkable regression of tumors in a mouse model of head and neck cancer.
By VUMC News and Communications
June 14, 2017

PET imaging to predict tumor response

A PET probe that detects the amino acid glutamine predicts whether tumors respond to certain targeted therapies in preclinical animal models.
By Leigh MacMillan
June 12, 2017

Repriming replication roadblocks

New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away.
By Sanjay Mishra
June 9, 2017

Flip side of gut protection

Vanderbilt investigators report that dysregulation of certain immune cells in the intestines may lead to inflammation and disease.
By Laura Daniel
May 18, 2017

Oxidative stress in tumors

Vanderbilt investigators have developed a new method for measuring oxidative stress in human tumors, which provides insight into cancer development.
By Sanjay Mishra
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