The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.

Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

The hormone erythropoietin (Epo) controls red blood cell production and synthetic forms of Epo treat multiple disorders. New Vanderbilt research details how Epo works.

Vanderbilt researchers have found that non-coding regions of the genome appear to contribute to the risk of autoimmune diseases and may represent attractive therapeutic targets.

Signaling through a complex of proteins called mTORC2 plays a role in breast cancer migration, invasion and metastasis, Vanderbilt researchers reported.

Bile acids produced by a western diet alter the composition of the gut microbiota and promote intestinal carcinogenesis.

The identification of a genetic culprit for hypoplastic left heart syndrome could lead to new treatments for the condition.