Aliquots - Research Briefs

Bypassing DNA damage

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

PET probe detects dying tumor cells

A novel PET imaging probe detects tumor cell death in vivo and could be useful for personalizing cancer medicine.

Potential mechanism for myeloma drug’s variable toxicity

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.

Target cell entry to halt Chikungunya virus

Understanding how chikungunya virus binds to and enters cells offers a new target for antiviral medications.

Increased cell permeability may protect from colitis

Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation.

New view of neurotransmitter transport

Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders.

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