Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

A novel PET imaging probe detects tumor cell death in vivo and could be useful for personalizing cancer medicine.

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.

Understanding how chikungunya virus binds to and enters cells offers a new target for antiviral medications.

Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation.

Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders.

A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis.