Health and Medicine Archive — Page 21 of 178

Syringe inserted into the bullseye of a black-and-yellow dartboard.
May 24, 2022

Diabetes, cardiovascular drug targets

Targeting receptors of the inflammatory lipid signaling molecule PGE2 may offer a new way to tackle both Type 2 diabetes and cardiovascular disease, Vanderbilt researchers have discovered.

White tablets spilled from an open orange prescription bottle, with additional pill bottles blurred in the background.
May 23, 2022

Pushing (anti-overdose) drugs

An automated alert to encourage clinicians to coprescribe naloxone for patients at risk of opioid overdose increased naloxone prescriptions per opioid prescription 16-fold.

Manual blood pressure monitor with a blue cuff, round pressure gauge, black inflation bulb, and attached stethoscope on a white background.
May 19, 2022

Genetics and blood pressure

Including polygenic risk scores for blood pressure may improve predictive models to identify people at risk for treatment-resistant hypertension.

Red heart-shaped object on blue electrocardiogram grid paper with black heartbeat waveforms.
May 19, 2022

A clue to an adverse drug event in children

Considering metabolic (CYP2D6) enzyme activity score and patient age may aid in determining an individual’s risk for an adverse event with administration of the anti-arrhythmic drug propafenone.

Stomach
May 19, 2022

Molecular ‘switch’ may illuminate stomach disorders

An international team that included researchers from Vanderbilt University Medical Center has discovered a molecular switch that induces rapid proliferation of zymogen granule-secreting chief cells in the stomach to regenerate damaged tissue.

Andy Weiss, PhD, Caitlin Murdoch, PhD, and colleagues have characterized the first zinc metallochaperone: a protein that puts zinc into other “client” proteins.
May 17, 2022

Study identifies first cellular “chaperone” for zinc, sheds light on worldwide public health problem of zinc deficiency

A team led by Vanderbilt researchers has described and characterized the first zinc metallochaperone: a protein that puts zinc into other “client” proteins.