antibiotic resistance

The increasingly antibiotic-resistant bacterium Acinetobacter baumannii requires zinc to cause infection, and Vanderbilt researchers have identified the zinc uptake system it uses.

A program in the Medical Intensive Care Unit has successfully removed penicillin allergy labels from more than 45 inpatients at high risk to receive antibiotics, but whose penicillin allergies were low risk.

Vanderbilt investigators have characterized how a new first-in-class antibacterial drug works, which will guide the development of additional compounds that overcome antibacterial resistance.

Vanderbilt researchers led by Eric Skaar are probing the mechanisms bacteria use when faced with nutrient starvation — a host defense strategy called “nutritional immunity.”

Jun. 28, 2018—The new factor, an enzyme involved in host-pathogen interactions, may be a viable target for treating staph infections.

A drug in use clinically to help make vaccines more effective may be a powerful new tool for fighting antibiotic-resistant infections.

Vanderbilt researchers have identified a unique example of communication between bacterial signaling systems, which may have relevance for antibiotic resistance.