Cancer drug discovery

January 21, 2021

WIN for blocking cancer growth

William Tansey and colleagues identified proteins that interact with the cancer drug target WDR5 and are important for cancer cell growth.

By Sarah E. Glass
July 8, 2019

Clinical study tests drug that may prevent cancer metastasis

A clinical study of a drug that may block cancer metastasis is currently enrolling patients at the Vanderbilt-Ingram Cancer Center.

By Leigh MacMillan
March 28, 2019

Cancer’s SOS

Stephen Fesik and colleagues are advancing cancer drug discovery with the characterization of small molecules that modulate RAS, an important target for anti-cancer therapies.

By Sanjay Mishra
bees
June 19, 2017

STINGing combination for cancer

A novel immunotherapy combination induced remarkable regression of tumors in a mouse model of head and neck cancer.

By VUMC News and Communications
February 20, 2017

Improving therapies for GI tumors

A signaling protein overexpressed in upper gastrointestinal cancers is an attractive therapeutic target.

By Leigh MacMillan
microscope
August 3, 2016

Kleberg Foundation grant bolsters cancer drug discovery efforts

The Robert J. Kleberg Jr. and Helen C. Kleberg Foundation has awarded a $3 million grant to Vanderbilt-Ingram Cancer Center (VICC) investigators in support of VICC’s drug discovery program. The gift awarded over the next three years from the private, San Antonio, Texas-based foundation will enable VICC researchers to pursue the development of new compounds to block the activity of cancer-causing genes and proteins that had previously been considered “undruggable.”

By VUMC News and Communications
June 23, 2016

VU takes key role in cancer drug discovery consortium

Vanderbilt University has been selected as one of seven Dedicated Centers in the nation for the next phase of the Chemical Biology Consortium (CBC), a national network of scientists on the leading edge of cancer drug discovery.
By Leigh MacMillan
May 5, 2016

Current cancer drug discovery method flawed: VUMC study

The primary method used to test compounds for anti-cancer activity in cells is flawed, Vanderbilt University researchers reported May 2 in Nature Methods.
By Leigh MacMillan
July 27, 2015

Anticancer olive compounds

Compounds found in olives and olive oil have anticancer activity, which may contribute to the cancer preventive properties attributed to the Mediterranean diet.
By Leigh MacMillan
April 8, 2015

Micelle “packets” deliver cancer drugs

Vanderbilt researchers designed micelle “packets” to selectively deliver anti-cancer drugs to breast cancer cells.
By VUMC News and Communications
April 3, 2015

Cancer signaling pathway blocker

Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer.
By VUMC News and Communications
February 25, 2015

Antibiotics with anticancer potential

A series of experimental antibiotics may be a good starting point for developing new anticancer drugs.
By Leigh MacMillan
November 12, 2014

New insight on oral cancer culprits

A new mouse model offers insight into the signaling pathways that control oral cancers – and a platform for testing anticancer therapeutics.
By Elizabeth Conrad