COX-2

May 4, 2023

Better adenoma detection

Fluorescent nanoparticles clearly identified colonic adenomas — precursors to colorectal cancer — in mice, and the formulation should translate to clinical use in humans.

By Sarah E. Glass
December 20, 2019

Reversing stress-related anxiety

Inhibiting COX-2 — an enzyme associated with inflammation — could provide a novel therapeutic approach for stress-related psychiatric disorders.

By VUMC News and Communications
January 19, 2017

COX-2 ‘conjugate’ may slow growth of some tumors: study

More than a decade after the anti-inflammatory drugs Vioxx and Bextra were pulled from the market because of a heightened risk of heart attack and stroke in some patients, COX-2 inhibitors may be on the verge of a comeback, this time as anti-cancer agents.

By Bill Snyder
October 12, 2016

Imaging probe for retinal disease

An imaging probe developed at Vanderbilt detects retinal inflammation early and may allow therapeutic intervention to prevent blindness.

By Leigh MacMillan
May 12, 2016

COX-2 blocker could help PTSD

COX-2 inhibitors – used clinically to reduce inflammation and pain – may find new applications for treating PTSD and other stress-related psychiatric disorders like major depression.

By Bill Snyder
October 2, 2015

The yin and yang of COX-2

New findings add to the understanding of how the enzyme COX-2 works, which is critical to the development of COX-2-targeted anti-inflammatory drugs.

By Sanjay Mishra
June 17, 2015

Lit up COX-2 cancer probe

A new imaging probe developed by Vanderbilt investigators enhances tumor visibility and has broad applications in diagnosing and monitoring patients with cancer.
By Henry H. Ong
October 2, 2014

Low-dose aspirin’s protective effect in cancer explained

For years, scientists have known that regular aspirin use may reduce the risk of cancer.
By VUMC News and Communications
August 5, 2013

Vanderbilt scientists discover potential new way to treat anxiety

Chemically modified inhibitors of the COX-2 enzyme relieve anxiety behaviors in mice by activating natural “endocannabinoids” without gastrointestinal side effects, Vanderbilt University scientists will report next week.
By Bill Snyder
March 10, 2012

Urine biomarker for colon cancer?

A molecule detectable in urine may be helpful in diagnosing colon cancer.
By VUMC News and Communications