Department of Biochemistry

March 14, 2019

Correctly copying DNA

A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.

By Sanjay Mishra
February 28, 2019

Achilles’ heel for kidney cancer

The discovery that kidney cells with mutations in a certain gene are sensitive to therapies called PI3K inhibitors opens new opportunities for applying precision medicine to cancer treatment.

By VUMC News and Communications
Kareem Mohni, PhD, left, and David Cortez, PhD, have discovered a new DNA repair pathway that guards against genomic mutations.
February 28, 2019

Novel DNA repair mechanism preserves genome integrity: study

Biochemistry investigators at Vanderbilt have discovered a new DNA repair mechanism that prevents gene mutations during DNA replication.

By Leigh MacMillan
February 14, 2019

The yin and yang of cell signaling

Larry Marnett and colleagues have explored the role of two enzymes in metabolizing molecules associated with cell proliferation, inflammatory processes and neurological diseases.

By Sanjay Mishra
January 17, 2019

Signals from the “conveyor belt”

Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.

By Bill Snyder
January 17, 2019

DNA’s on/off switch

DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.

By Bill Snyder
October 25, 2018

Rothamel selected as Vanderbilt Prize Student Scholar

Katherine Rothamel, a PhD student in the Department of Biochemistry at Vanderbilt University School of Medicine, has been selected as the 2017 Vanderbilt Prize Student Scholar.
By Bill Snyder
August 30, 2018

Energetic gene switch

New findings link flux through glycolysis, which produces cellular energy, with transcription and gene expression via histone modification.
By Bill Snyder
August 23, 2018

Enzyme helps build motor that drives neuron death

Vanderbilt scientists have discovered a signaling mechanism that tells neurons to die, findings that could lead to new treatments for neurodegenerative diseases.
By VUMC News and Communications
August 2, 2018

Genetic balancing act

New findings about proteins involved in DNA repair are important for understanding why some cancers are more or less resistant to certain therapies.
By Meredith Jackson
August 2, 2018

How asters form

New findings shed light on the formation of microtubule structures that support cellular processes ranging from cell division to intracellular transport.
By VUMC News and Communications
June 11, 2018

Confronting TB resistance

Vanderbilt researchers describe how certain tuberculosis treatments work and suggest these medications may overcome the threat of drug-resistant tuberculosis.
By Niyati Vachharajani
April 26, 2018

Self care, mindfulness key to decreasing burnout: speaker

It’s not often that a keynote speaker will ask his audience to close their eyes and tune him out, but that’s what Aviad “Adi” Haramati, PhD, did when delivering the 2018 John E. Chapman Lecture.
By Kathy Whitney
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