Department of Biochemistry

Assembling cell power plant machinery

Tina Iverson and colleagues provide a structural view into the assembly of a protein machine essential for cellular energy production.

Cellular antiviral defenses

A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.

Probing DNA damage repair

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works.

Probing innate immunity

Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA.

New method captures early viral-host protein interactions

Researchers have developed a method to identify the primary interactions between incoming viral RNA genomes and host proteins.

A dual-purpose metabolic switch

John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules.

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