New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.

The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.

Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

Researchers at Vanderbilt University Medical Center (VUMC) have discovered a protein that may lead to a new way to prevent resistance and improve outcomes for patients whose cancers have mutations in the tumor suppressor gene BRCA2.

New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away.

Vanderbilt investigators have developed a new method for measuring oxidative stress in human tumors, which provides insight into cancer development.

A new protein structure may guide the development of Alzheimer's therapeutics.