A first-of-its-kind mouse model may help reveal mechanistic underpinnings for the altered behaviors of autism spectrum disorder.

Vanderbilt Eye Institute researchers have discovered that an imbalance in the ionic environment of retinal ganglion cells may contribute to functional impairments in glaucoma.

Joel Hardman, PhD, an internationally recognized scientist and educator who chaired the Department of Pharmacology at Vanderbilt University School of Medicine from 1975 to 1990, died June 30, 2019 in Hoosick Falls, New York, after a lengthy illness. He was 85.

Ariel Deutch and colleagues have discovered that overactive brain immune cells during adolescence may contribute to schizophrenia.

Understanding details of how arrestins deactivate signaling by G-protein coupled receptors is key to the design of new therapeutics aimed at these cellular "inboxes" that are targeted by up to half of all pharmaceuticals.

Jonathan Schoenecker and colleagues have discovered a new mechanism for the formation of bone in soft tissues — a complication of severe injuries that causes pain and limits mobility.

Stephen Fesik and colleagues are advancing cancer drug discovery with the characterization of small molecules that modulate RAS, an important target for anti-cancer therapies.