Department of Veterans Affairs

December 14, 2015

DISSECTing cell signaling networks

Vanderbilt researchers have developed a new method to study cell signaling networks at single-cell resolution.

By Leigh MacMillan
green traffic light
December 3, 2015

Microtubules act as cellular ‘rheostat’ to control insulin secretion

Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell.

By Leigh MacMillan
November 12, 2015

Immune system a must for kidney repair

A signaling protein that is essential for recovery from acute kidney injury works by increasing the population of tissue-repairing immune cells.

By Lorena Infante
November 4, 2015

Detect and defend against pathogens

Understanding factors, such as the receptor TLR9, that detect and defend against pathogens may lead to therapeutic approaches that promote an effective immune response to treat infections.

By Leigh MacMillan
October 29, 2015

Inflammation, obesity and diabetes

Vanderbilt study adds to the mounting role for inflammatory signaling in obesity.

By Leigh MacMillan
October 16, 2015

Healing without scarring

Drugs that inhibit the Wnt signaling pathway can regenerate injured skin and may be useful in treating fibromatosis, degenerative joint disease and cancer.

By Sanjay Mishra
October 8, 2015

Depression poses heart risk for HIV patients: study

The first study to suggest that major depressive disorder (MDD) is an independent risk factor for heart failure in HIV-positive adults has been published in Circulation.
By Kathy Whitney
September 8, 2015

Immune cells and obesity

Understanding how macrophage immune cells accumulate in fat tissue and contribute to the pathology of obesity could lead to the development of novel therapeutics for metabolic disorders.
By Leigh MacMillan
August 20, 2015

New therapeutic target for diabetes

The factor FoxM1 increases the proliferation and function of insulin-producing beta cells, making it an attractive therapeutic target for diabetes.
By Leigh MacMillan
July 23, 2015

Targeting bone metastasis

The rigidity of the bone extracellular matrix increases the ability of tumor cells to destroy bone, suggesting new targets for anticancer drug development.
By VUMC News and Communications
July 23, 2015

Study explores protein’s role in inflammation-associated cancer

An antioxidant protein may protect against colon cancer that develops in patients with inflammatory bowel disease, suggesting new strategies for reducing colon cancer risk in these patients.
By Leigh MacMillan
July 13, 2015

Hhex on cancer

A new mouse model demonstrates that the Hhex gene – which is linked to blood cancers – is critical for normal blood cell production.
By Henry H. Ong
July 10, 2015

Delivering cells for heart repair

A polymer hydrogel material developed by Vanderbilt scientists improved the delivery of stem cells for heart repair.
By Leigh MacMillan
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