Department of Veterans Affairs

May 15, 2015

Boosting cell-based heart repair

A metabolic change in adult stem cells makes them less “fit” for regenerative heart therapies, suggesting that strategies to prevent this response may boost the therapeutic usefulness of the cells.

By Leigh MacMillan
May 14, 2015

Insights on lysosomal storage diseases

A novel mechanism could point to new therapies for a group of inherited diseases that share pathological features.

By Leigh MacMillan
May 4, 2015

Kids more likely to react to blood transfusions

Pediatric patients have a significantly higher incidence of transfusion reactions compared to adults, according to a study by Vanderbilt University researchers.

By Bill Snyder
April 20, 2015

Boosting beta cells in diabetes

New findings suggest that it might be possible to treat diabetes by regenerating insulin-producing beta cells in the pancreas.

By Leigh MacMillan
April 16, 2015

Surprising finding in the kidney

TGF-beta signaling in the kidney was thought to be a target for reducing renal fibrosis, but Vanderbilt researchers report that fibrosis still occurs in the absence of TGF-beta signaling.

By VUMC News and Communications
April 6, 2015

New player in heart cell growth

Vanderbilt researchers have identified a new protein involved in heart cell growth, which could improve understanding of pathologic cardiac hypertrophy.

By Leigh MacMillan
December 17, 2014

Target for atherosclerosis therapies

A newly identified “atheroprotective” gene is a tool for exploring plaque pathophysiology and may be a good target for therapies to slow atherosclerosis progression.
By Leigh MacMillan
November 6, 2014

Immune cell activity and melanoma

The activity of a certain factor in immune cells is essential for an anti-tumor response, emphasizing the need to consider the effects of anti-cancer therapies on immune cells.
By VUMC News and Communications
September 11, 2014

Skin cancer risks higher for soldiers serving abroad

Soldiers deployed to tropical and sunny climates are coming home with increased risk factors for a threat far from the battlefield: skin cancer.
By Wayne Wood
June 16, 2014

Factor impacts bone toughness

The factor ATF4 has a role in the toughness of bone and its resistance to fracture, suggesting new therapeutic targets.
By Leigh MacMillan
April 30, 2014

Potential mechanism for myeloma drug’s variable toxicity

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.
By Leigh MacMillan
April 25, 2014

Increased cell permeability may protect from colitis

Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation.
By Leigh MacMillan
March 17, 2014

Delirium increases long-term disability

Patients who suffer a longer duration of delirium in the intensive care unit are more likely to experience long-term disability after discharge.
By Leigh MacMillan
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