Division of Clinical Pharmacology

June 16, 2022

BMI genetics influence heart function

Vanderbilt researchers have discovered that a genetic predisposition to elevated body mass index increases the risk of diastolic dysfunction — a cardiac condition that can lead to heart failure.

By Leigh MacMillan
April 11, 2022

Peptides promote AFib arrhythmia

Peptide oligomers have detrimental metabolic effects and cause pro-arrhythmic electrophysiological changes in heart atria, suggesting they may contribute to atrial fibrillation.

By Leigh MacMillan
February 24, 2022

VUMC researchers find clue to drug-induced arrhythmias

Vanderbilt University Medical Center researchers have made a fundamental discovery about how the heart compensates for genetic variations that otherwise could trigger abnormal and potentially fatal heart rhythms.

By Bill Snyder
July 12, 2021

Probing statin-associated diseases with genetics

Vanderbilt researchers used genetics tools and biobanks with linked electronic health records to explore the associations between statins and noncardiovascular diseases.

By Leigh MacMillan
(iStock photo)
May 25, 2021

Heat for hypertension in autonomic failure

Heat therapy could offer a novel nonpharmacologic approach for treating the overnight hypertension that affects patients with autonomic failure.

By Leigh MacMillan
February 4, 2021

New clue to postural tachycardia

Insight into the pathophysiology of an enigmatic and debilitating disease suggests new treatment approaches.

By Bill Snyder
January 12, 2021

Mitochondrial stress and hypertension

Oxidative stress and toxic products called isolevuglandins in mitochondria play a role in endothelial dysfunction and hypertension — and getting rid of them with a special “scavenger” molecule has therapeutic potential.
By Leigh MacMillan
August 20, 2020

Salt, immune cells and hypertension

Excess dietary salt activates immune cells to induce inflammation and hypertension, supporting current recommendations for low sodium consumption.
By Leigh MacMillan
July 9, 2020

Autonomic disorders clinical fellowship created

A new Clinical Fellowship in Autonomic Disorders, administered through the Division of Clinical Pharmacology in the Department of Medicine at Vanderbilt University Medical Center, will be one of only four accredited fellowship programs in autonomic disorders in the country.
By Bill Snyder
June 12, 2020

Robotic technology speeds arrhythmia gene classification

Vanderbilt University Medical Center investigators have used high-throughput robotic technology to rapidly study and classify variations in a gene linked to heart rhythm disorders and cardiac conditions.
By Leigh MacMillan
September 5, 2019

How salt increases blood pressure

Vanderbilt researchers have discovered that a protein called SGK1 in immune cells is activated by sodium, leading to the development of salt-sensitive hypertension.
By Leigh MacMillan
August 1, 2019

Oates recalled as iconic leader, physician, scientist

John Oates, MD, an internationally known physician at Vanderbilt University School of Medicine and a founding father of the discipline of Clinical Pharmacology, died Tuesday (July 30) in Nashville after a short illness. He was 87.
By Bill Snyder and Leigh MacMillan
July 18, 2019

Madhur receives Presidential Early Career Award

Meena Madhur, MD, PhD, has received a Presidential Early Career Award for Scientists and Engineers.
By Leigh MacMillan