DNA repair

Madison Adolph, PhD, left, David Cortez, PhD, and Archana Krishnamoorthy are studying fundamental processes involved in DNA replication.
July 22, 2021

Researchers discover that protein switches functions to regulate DNA replication

Vanderbilt biochemists have discovered what the DNA damage response protein RADX does — and how it does it.

By Leigh MacMillan
June 22, 2021

Treating metastatic prostate cancer

An indirect comparative effectiveness study using published data suggests that the targeted therapy olaparib should be re-evaluated for treating metastatic prostate cancer.

By Leigh MacMillan
June 18, 2020

Probing DNA damage repair

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works.

By Leigh MacMillan
David Cortez, PhD, left, Petria Thompson, Katherine Amidon, Brandt Eichman, PhD, and colleagues are studying how a DNA repair pathway protein shields sites of damage to avoid mutations.
July 25, 2019

Team’s study reveals details of new DNA repair pathway

Investigators have discovered how a DNA repair pathway protein shields sites of damage to avoid mutations and maintain genome integrity.

By Leigh MacMillan
April 11, 2019

Pathways of radiosensitization

Austin Kirschner and colleagues demonstrate how a hormone therapy for prostate cancer improves radiation’s tumor-killing power.

By Leigh MacMillan
Kareem Mohni, PhD, left, and David Cortez, PhD, have discovered a new DNA repair pathway that guards against genomic mutations.
February 28, 2019

Novel DNA repair mechanism preserves genome integrity: study

Biochemistry investigators at Vanderbilt have discovered a new DNA repair mechanism that prevents gene mutations during DNA replication.

By Leigh MacMillan
August 2, 2018

Genetic balancing act

New findings about proteins involved in DNA repair are important for understanding why some cancers are more or less resistant to certain therapies.
By Meredith Jackson
July 19, 2018

New player in DNA damage repair

New findings open opportunities to understand mechanisms of DNA repair for a toxic form of DNA damage.
By Leigh MacMillan
December 5, 2017

DNA damage repair: molecular insights

Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.
By VUMC News and Communications
April 14, 2017

A new mode of DNA repair

Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair.
By Leigh MacMillan
April 15, 2016

Mechanism of a DNA repair protein

Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.
By Sanjay Mishra
January 8, 2016

Copying chromosome caps

Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports.
By Leigh MacMillan
November 12, 2015

Study helps clarify components of DNA ‘copy machine’

Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.
By Leigh MacMillan