infection

Novel drugs have potential for treating tuberculosis

Drug-resistant tuberculosis is on the rise, and novel antibacterial drugs called SPTs have potential for treating the deadly lung infection.

The study team included, from left, Linh Tran, Ruben Barricade, PhD, Jaren Perez, and Xin Zhen. (photo by Susan Urmy)

Study reveals new genetic disorder that causes susceptibility to opportunistic infections

An international consortium co-led by Vanderbilt’s Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including a life-threatening fungal pneumonia. 

close up of blood vessels

Vascular dysfunction during sepsis

Regulation of the enzyme Sirtuin 1 in blood vessel endothelial cells may drive altered metabolism and vascular dysfunction during sepsis, Vanderbilt researchers have discovered.

Molecular imaging of C. diff infection

C. difficile — the leading cause of hospital-associated intestinal infections — induces a rapid influx of bile acids into the gut, which could provide a novel target for blocking infection.

Transporter’s role in gut barrier

A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections.

Imaging host-pathogen battle for metal

An unprecedented view of bacterial products within infected tissues opens new opportunities to explore infection biology and devise novel therapeutic strategies.

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