Journal of Biological Chemistry

February 24, 2016

Liver balancing act

Vanderbilt researchers have defined a mechanism that limits liver cell proliferation after injury in order to preserve critical metabolic functions.

By VUMC News and Communications
model of DNA double helix
January 22, 2016

Faulty building blocks in DNA

An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

By Bill Snyder
aspergillus culture
October 7, 2015

Rational design of novel antifungals

Structural and molecular details of an anti-fungal target’s interaction with inhibitors suggest ways to design better treatments for fungal infections.

By VUMC News and Communications
September 9, 2015

How to build a basement

Understanding the action of a certain enzyme will shed light on basement membrane function, and on disorders ranging from diabetic kidney disease to cancer.

By Sanjay Mishra
September 4, 2015

Vitamin C protects blood vessel lining

Dietary vitamin C may maintain healthy blood vessels in patients with inflammatory diseases.

By Leigh MacMillan
August 25, 2015

How the cell makes morphine

Vanderbilt investigators have discovered how mammals, including humans, produce the painkiller morphine.

By Sanjay Mishra
July 9, 2015

Guengerich named interim editor of noted journal JBC

Vanderbilt University’s F. Peter (Fred) Guengerich, Ph.D., has been named interim editor-in-chief of the Journal of Biological Chemistry (JBC).
By Bill Snyder
May 1, 2015

New player in neuronal communication

Vanderbilt researchers have discovered a novel mechanism for the development of dendritic spines – sites of nerve cell communication.
By Leigh MacMillan
August 20, 2014

Enzyme holds the door for influenza

Compounds developed at Vanderbilt University may offer a new way to block influenza infection.
By VUMC News and Communications
August 1, 2014

Anti-inflammatory protein “rheostat” sheds light on leaky blood vessels

Vanderbilt researchers have discovered that the protein CRADD counteracts inflammatory injury to endothelial cells, which could assist the development of new therapies for inflammatory vascular disorders.
By Emily Poulin
May 14, 2014

CaMKII enhances insulin secretion

The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion.
By VUMC News and Communications
May 9, 2014

Bypassing DNA damage

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.
By VUMC News and Communications
January 16, 2014

New approach may halt glioblastoma’s ability to grow

Vanderbilt University researchers have discovered a “backdoor” approach to blocking an enzyme that fuels the growth of glioblastoma, the most common and most fatal form of brain cancer.
By Bill Snyder