Journal of Clinical Investigation

baby in crib
July 24, 2014

Team spots trigger for rare diarrheal disease in infants

Researchers at Vanderbilt University, the University of Arizona and Phoenix Children’s Hospital have discovered what triggers a rare but devastating diarrheal disease in newborns that is fatal without intravenous feeding or intestinal transplant.

By Bill Snyder
obesity or overweight belly
July 17, 2014

Study examines therapeutic bacteria’s ability to prevent obesity

Engineered bacteria that produce a therapeutic compound in the gut prevent obesity in mice, Vanderbilt University investigators have discovered.

By Leigh MacMillan
July 10, 2014

Molecular ‘chat’ holds kidney fibrosis clues

A novel molecular “conversation” regulates kidney fibrosis – the final result of end-stage chronic kidney disease – suggesting new treatment options for this currently irreversible process.

By Leigh MacMillan
April 10, 2014

Study tracks new lung cancer drug target

Researchers at Vanderbilt University have identified a potential new drug target in subtypes of lung cancer that are difficult to treat.

By Bill Snyder
April 3, 2014

Protein’s role in spread of colon cancer studied

One of the most formidable weapons in a cancer’s arsenal is the ability to spread to other organs.

By VUMC News and Communications
March 19, 2014

Small molecule protects kidney filter

A compound identified at Vanderbilt has therapeutic potential in protecting the kidney filter barrier.

By Bill Snyder
February 20, 2014

Studies shed new light on breast cancer development

Rebecca Cook, Ph.D., assistant professor of Cancer Biology, has spent her life trying to understand what makes things grow, from seedlings in soil to tumor cells in the body.
By VUMC News and Communications
September 17, 2013

Researchers identify novel biomarker for diabetes risk

Researchers at the Vanderbilt Heart and Vascular Institute and Massachusetts General Hospital have identified a biomarker that can predict diabetes risk up to 10 years before onset of the disease.
By Kathy Whitney
June 6, 2013

Study tracks skin salt’s role in blood pressure control

Clinical pharmacologist Jens Titze, M.D., and his colleagues have identified a new cast of cells and molecules that function in the skin to control sodium balance and blood pressure.
By Leigh MacMillan
May 30, 2013

Study lays groundwork for rational T cell vaccine design

Vanderbilt University investigators have developed a new strategy for identifying the “bits” of a pathogen that spark a protective immune response.
By Leigh MacMillan
March 21, 2013

Breast cancer study explores therapy to slow recurrence

Many patients with triple-negative breast cancer (TNBC) have recurrence of their disease after an initial response to chemotherapy because the cancer cells have become resistant to treatment. TNBC has a lower survival rate because of this pattern of resistance and there are no targeted agents to treat this form of breast cancer.
By VUMC News and Communications
February 6, 2013

Linking oxygen, iron and red blood cells

The HIF oxygen-sensing pathway and its responses to low oxygen may be targeted for treatments of anemia and disorders of iron balance.
By Leigh MacMillan
January 31, 2013

Do-it-yourself repair in the kidney

The kidney can mediate its own repair through proliferation of resident immune system cells.
By Leigh MacMillan