Vanderbilt investigators are probing the response to a bacterial toxin as a clinical assessment of immune function.

The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection.

Modulation of T cell metabolism thus may represent a new therapeutic avenue for leukemia patients.

Immune cells that recognize self antigens (e.g. insulin), but are functionally silent, can trigger autoimmune diseases such as diabetes.

The factor STAT6 appears to play a role in the pathogenesis of an inflammatory bowel disease, suggesting it may be a promising target for new treatments.

Low oxygen – and the activation of factors that respond to this situation – may be protective in chronic kidney disease.