multidrug transporter

May 29, 2019

Study details regulation of a multi-drug transporter

P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.

By Leigh MacMillan
July 19, 2018

Fueling the MATE transporter

Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.

By Sanjay Mishra
water drops splashing against solid surface
July 14, 2016

Membrane fats impact drug transporter

New studies of a membrane transporter could explain antibiotic resistance – and lead to novel ways to combat it.

By Bill Snyder
June 13, 2014

How ABC transporters move molecules

New views of how transporters move molecules across cell membranes are key to understanding how these proteins impact tumor cell drug resistance and inherited diseases such as cystic fibrosis.

By Leigh MacMillan
December 12, 2013

Proton transfer powers multidrug resistance: study

Vanderbilt University researchers and their Belgian colleagues have discovered the mechanism behind a multidrug transporter. Their findings, posted this week by Nature Chemical Biology, could lead to new treatments for multidrug resistant bacterial infections.

By VUMC News and Communications