NHGRI Archive — Page 1 of 3

Stylized blue profile of a human face formed from a wireframe grid, merging with glowing circuit-board traces and digital data patterns.
May 9, 2023

Neural networks probe proteins

A machine learning method based on neural networks outperformed a mutational scanning model at identifying disease-causing mutations in an Alzheimer’s disease protein, suggesting the method could be useful for facilitating therapeutic design.

Silhouette of a person facing a glowing DNA double helix, overlaid with floating binary digits in a blue-toned digital composition.
April 20, 2023

Genetics and chronic pain

Polygenic risk scores — scores that reflect the influence of common genetic variants — could be used to predict the likelihood of developing chronic overlapping pain conditions and guide biomarker and targeted prevention efforts.

Green sugar cane field with vehicle tracks in the foreground and a cluster of high-rise buildings on the horizon beneath a cloudy sky.
April 11, 2023

COVID on Twitter: town vs. country

A natural language processing analysis of 407 million tweets from May 2020 to January 2022 captures the rural-urban divide regarding COVID-19.

Futuristic blue digital illustration combining a DNA double helix with glowing circuit-board patterns, binary-style numbers, and vertical data streams.
March 28, 2023

Inflammation implicated in exfoliation syndrome

Computational genetics tools have implicated inflammatory pathways in exfoliation syndrome, the most common cause of secondary glaucoma, which can result in blindness.

Healthcare professional holding a transparent tablet displaying a chest X-ray and medical data, surrounded by digitally rendered virus particles and interface graphics.
September 8, 2022

PheWAS reveals post-COVID-19 diagnoses

Using a high-throughput informatics technique and electronic health records, Vanderbilt researchers found that COVID-19 survivors had an increased risk for more than 40 new diagnoses.

Illustration of red blood cells and several white blood cells suspended in a red bloodstream.
August 11, 2022

Genotype-specific blood counts

Vanderbilt researchers report genotype-specific reference ranges to improve interpretation of laboratory blood results in African Americans with a common gene variant that lowers white blood cell counts.