NHLBI

January 27, 2022

Impaired neutrophils in autoimmunity

Vanderbilt researchers help answer the question of why patients with autoimmune diseases like lupus are more susceptible to bacterial infections: their neutrophils have impaired antibacterial activity.

By Leigh MacMillan
From left, J.Court Reese, Stephanie Moore-Lotridge, PhD, Breanne Gibson, PhD, and Jonathan Schoenecker, MD, PhD, are discovering ways to prevent adverse outcomes in orthopaedic surgery.
January 19, 2022

Study identifies molecular trigger of severe injury-induced inflammatory response

Vanderbilt researchers have discovered that early inappropriate activation of the enzyme plasmin caused by severe injury is a trigger of systemic inflammatory response syndrome and resulting organ failure.

By Leigh MacMillan
January 13, 2022

The role of integrins in kidney “integrity”

Receptors called integrins play a critical role in maintaining the structure of the kidney, Vanderbilt researchers have discovered.

By Bill Snyder
December 9, 2021

Cell signaling targets in leukemia

Vanderbilt researchers identified a critical role for IL-1beta signaling in leukemia cells with a certain mutation, suggesting this pathway may be a good target for novel treatments.

By Leigh MacMillan
Ayaka Sugiura and Jeff Rathmell, PhD, are studying a metabolic enzyme involved in T cell function that may offer a new target for anti-inflammatory therapeutics.
November 11, 2021

CRISPR screen identifies new anti-inflammatory drug target

A novel CRISPR screen developed by Vanderbilt researchers identified a promising new target for anti-inflammatory therapeutics.

By Leigh MacMillan
Insulin in vials
November 11, 2021

New way to bEET insulin resistance

Signaling molecules called EETs could improve insulin resistance, a primary risk factor for Type 2 diabetes and cardiovascular disease, Vanderbilt researchers have discovered.

By Bill Snyder
October 28, 2021

Pancreatic beta-cell booster

Blocking inflammatory signaling improves beta-cell characteristics in a mouse model of type 2 diabetes and may provide added benefits to GLP-1R diabetes medications.
By Leigh MacMillan
October 14, 2021

Tea drinking and high blood pressure

Habitual tea drinking is associated with a slightly higher risk of hypertension in middle-aged and older Chinese adults, which warrants confirmation by long-term intervention studies, researchers say.
By Sarah E. Glass
October 4, 2021

Neurologic complications of the flu

Neurologic complications are common in children hospitalized with influenza, especially those with chronic neurologic conditions, and are associated with worse outcomes.
By Leigh MacMillan
September 16, 2021

‘Pre-conditioning’ restores immune tolerance

A treatment targeting T-cell metabolism could reinvigorate immune tolerance mechanisms to combat autoimmune disease and transplant rejection, Vanderbilt researchers discovered.
By Bill Snyder
September 10, 2021

Caught in a web: study reveals that immune cells cooperate to trap and kill bacteria

Vanderbilt researchers have identified a new antibacterial mechanism that could inspire novel strategies for combating staph and other extracellular bacterial pathogens.
By Leigh MacMillan
July 12, 2021

Probing statin-associated diseases with genetics

Vanderbilt researchers used genetics tools and biobanks with linked electronic health records to explore the associations between statins and noncardiovascular diseases.
By Leigh MacMillan
July 8, 2021

Genetics of hydrocephalus

Fluid build-up in the brain — hydrocephalus — increases pressure and risk for brain damage; Vanderbilt researchers have now identified genes and signaling pathways associated with the condition.
By Leigh MacMillan
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