NIDDK

August 31, 2016

Proliferative capacity of neuroblastoma

The sphere-forming frequency of neuroblastoma cells is a measure of their proliferative capacity and could help guide treatment strategies for neuroblastoma.

By Sanjay Mishra
pair of tango dancers outdoors
June 23, 2016

It takes two to tango: beta cell development

Defining the genes required for the function of insulin-producing beta cells is crucial for ongoing efforts to develop a cell-based therapy for diabetes.

By Bill Snyder
March 8, 2016

Fat hormone’s role in zebrafish

The hormone leptin regulates glucose balance, but not fat stores, in zebrafish.

By Leigh MacMillan
February 24, 2016

Liver balancing act

Vanderbilt researchers have defined a mechanism that limits liver cell proliferation after injury in order to preserve critical metabolic functions.

By VUMC News and Communications
February 8, 2016

Building intestinal brush borders

Studies of the molecular complex that helps build specialized cellular surfaces could shed light on the mechanisms underlying a genetic deaf-blindness syndrome accompanied by intestinal disease.

By Leigh MacMillan
December 14, 2015

DISSECTing cell signaling networks

Vanderbilt researchers have developed a new method to study cell signaling networks at single-cell resolution.

By Leigh MacMillan
December 3, 2015

Microtubules act as cellular ‘rheostat’ to control insulin secretion

Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell.
By Leigh MacMillan
November 18, 2015

Fighting type 2 diabetes with FGF1

The growth factor FGF1 induces the growth of new insulin-producing beta cells and may help treat type 2 diabetes.
By VUMC News and Communications
November 12, 2015

Immune system a must for kidney repair

A signaling protein that is essential for recovery from acute kidney injury works by increasing the population of tissue-repairing immune cells.
By Lorena Infante
November 4, 2015

Detect and defend against pathogens

Understanding factors, such as the receptor TLR9, that detect and defend against pathogens may lead to therapeutic approaches that promote an effective immune response to treat infections.
By Leigh MacMillan
October 29, 2015

Inflammation, obesity and diabetes

Vanderbilt study adds to the mounting role for inflammatory signaling in obesity.
By Leigh MacMillan
October 1, 2015

Tolerating a transplant

A new genetic model has generated new strategies for promoting tolerance to transplants – and improving long-term transplant outcomes – in the background of autoimmune disease.
By Leigh MacMillan
September 9, 2015

How to build a basement

Understanding the action of a certain enzyme will shed light on basement membrane function, and on disorders ranging from diabetic kidney disease to cancer.
By Sanjay Mishra
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