NIDDK Archive — Page 3 of 22

Top-down view of socked feet standing on a glass bathroom scale against a blue background; the display is blank or unreadable.
August 25, 2022

Inflammatory driver of obesity

Blocking the EGF receptor signaling pathway in immune system macrophages represents a new target for improving insulin resistance in people with obesity.

Close-up 3D rendering of densely packed pink, rounded finger-like biological structures, with larger forms in the foreground and smaller ones receding into the background.
July 12, 2022

Probing the tumor microenvironment

Vanderbilt researchers used single-cell sequencing, imaging, and computational approaches to characterize the colonic tumor microenvironment, providing important insights to the components that play roles in colorectal tumor pathogenesis.

Syringe inserted into the bullseye of a black-and-yellow dartboard.
May 24, 2022

Diabetes, cardiovascular drug targets

Targeting receptors of the inflammatory lipid signaling molecule PGE2 may offer a new way to tackle both Type 2 diabetes and cardiovascular disease, Vanderbilt researchers have discovered.

Manual blood pressure monitor with a blue cuff, round pressure gauge, black inflation bulb, and attached stethoscope on a white background.
May 19, 2022

Genetics and blood pressure

Including polygenic risk scores for blood pressure may improve predictive models to identify people at risk for treatment-resistant hypertension.

Stylized close-up of dark molecular ball-and-stick structures against a bright blue-white background.
March 24, 2022

Reducing obesity-related inflammation

A treatment that increases levels of lipid signaling molecules reduced adipose tissue inflammation in obese adults, suggesting this pathway may be a valuable target for modulating fat and systemic inflammation.

3D illustration of a pink colon formed from interlocking puzzle pieces, with several pieces missing and two gloved hands using surgical instruments to fit pieces into the colon.
February 10, 2022

Diverticulitis surgery: guidelines needed

Surgical removal of the colon for recurrent diverticulosis varies by geographic region and is associated with surgeon and hospital factors; stronger national guidelines are needed, Vanderbilt researchers report.