NIGMS

August 30, 2018

A brain-builder called “Shh”

New findings demonstrate a previously unappreciated role of Shh signaling activity in the proliferation of CGNPs — the presumed cell-of-origin for a subset of the malignant pediatric brain tumor medulloblastoma.

By VUMC News and Communications
August 30, 2018

Investigators find that bile acids reduce cocaine reward

Bile acids — gut compounds that aid in the digestion of dietary fats — reduce the desire for cocaine, according to a new study by researchers at Vanderbilt and the University of Alabama at Birmingham.

By Leigh MacMillan
August 16, 2018

Predictive models for gene regulation

Using new computational approaches to understand the behavior of cells should aid efforts to predict how mutations affect cell function and how diseases respond to drug combinations.

By Bill Snyder
August 2, 2018

Repairs in the basement membrane

Studies in fruit flies have shed light on how the basement membrane — a sheet-like scaffold that wraps around most animal tissues — is repaired after being damaged.

By Sanjay Mishra
August 2, 2018

Genetic balancing act

New findings about proteins involved in DNA repair are important for understanding why some cancers are more or less resistant to certain therapies.

By Meredith Jackson
August 2, 2018

How asters form

New findings shed light on the formation of microtubule structures that support cellular processes ranging from cell division to intracellular transport.

By VUMC News and Communications
August 2, 2018

Connecting an asthma gene to leukemia

A receptor previously implicated in asthma may also play roles in other allergic diseases and in leukemia, Vanderbilt researchers have discovered.
By Leigh MacMillan
July 19, 2018

Novel insights on “leaky” gut

A protein involved in binding cells together helps maintain the integrity of the intestinal mucosa and plays a protective role in ulcerative colitis.
By Niyati Vachharajani
July 19, 2018

New player in DNA damage repair

New findings open opportunities to understand mechanisms of DNA repair for a toxic form of DNA damage.
By Leigh MacMillan
July 19, 2018

Fueling the MATE transporter

Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.
By Sanjay Mishra
July 2, 2018

SMAD4 clue to colon cancer

Loss of a gene that is part of the TGF-beta signaling pathway increased inflammation in the colon and was observed in half of human colitis-associated cancers.
By Bill Snyder
June 28, 2018

New staph virulence factor

Jun. 28, 2018—The new factor, an enzyme involved in host-pathogen interactions, may be a viable target for treating staph infections.
By Leigh MacMillan
June 13, 2018

Novel infection fighter

A drug in use clinically to help make vaccines more effective may be a powerful new tool for fighting antibiotic-resistant infections.
By Meredith Jackson
1 … 7 8 9 10 11 … 22