NKCC1

Gene mutations impair gut barrier

Mutations in a cell membrane transporter protein impair the integrity of the gut lining, contributing to chronic gastrointestinal distress for people with the mutations, Vanderbilt researchers report.

Study explores possible drug target for neurological problems

A team at Case Western Reserve University and Vanderbilt University Medical Center has determined with atomic-level precision how two established drugs bind to and alter the conformation of a cell membrane transporter protein called NKCC1, shutting down its activity.