science Archive — Page 1 of 5

Illustration of intertwined DNA double helices against a glowing blue and purple background.
October 21, 2021

Study links genetic variants, protein expression and human diseases

An international research team has developed a new resource that connects genetic variants and protein expression, which is expected to speed the identification of genes that cause disease — and point to novel treatment strategies.

Mariana Byndloss, DVM, PhD, Woongjae Yoo, PhD, and colleagues are studying how a high-fat diet may contribute to heart disease. (Photo taken prior to revised masking guidelines.)
August 12, 2021

Study reveals missing link between high-fat diet, microbiota and heart disease

A high-fat diet disrupts the biology of the gut’s inner lining and its microbial communities — and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science.

Portrait of Mariana Byndloss, DVM, PhD, smiling against a brown background.
July 9, 2020

VUMC’s Byndloss recognized for microbiome research

Mariana Byndloss, DVM, PhD, assistant professor of Pathology, Microbiology and Immunology, has been selected as a runner-up of the inaugural NOSTER & Science Microbiome Prize.

Stylized side-profile illustration of a human head showing a glowing, interconnected brain and nervous system in blue, purple, and pink.
December 5, 2019

Study reveals mysteries of critical brain receptor complex

Poorly functioning AMPARs have been linked to a wide range of neurological and psychiatric disorders including seizures, Alzheimer’s disease, major depression and autism spectrum disorder. Understanding how AMPARs are formed and operate is essential for the rational design of pharmacological compounds that, by tuning AMPAR activity up or down, could improve treatment of these conditions.

Three researchers pose in a laboratory beside large scientific instruments and a connected metal vacuum line.
May 29, 2019

Study details regulation of a multi-drug transporter

P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.

Illustration of two purple neuron endings facing each other across a synaptic gap, with glowing orange-yellow neurotransmitter particles between them.
March 7, 2019

Vanderbilt scientists report new modeling of brain signaling

The release of neurotransmitters and hormones in the body is tightly controlled by complex protein machinery embedded in cell membranes.