transporter

November 7, 2022

Gene mutations impair gut barrier

Mutations in a cell membrane transporter protein impair the integrity of the gut lining, contributing to chronic gastrointestinal distress for people with the mutations, Vanderbilt researchers report.

By Kelsey Pinckard
October 6, 2022

Gene tied to childhood epilepsy

Data drawn from four unrelated patients with a childhood epilepsy syndrome — and from in vitro and in vivo studies — link novel variants in a GABA transporter gene to seizure activity, Vanderbilt researchers reported.

By Paul Govern
April 16, 2020

Transporter’s role in gut barrier

A disease-associated mutation in a transporter protein impairs gut barrier function, leading to gastrointestinal disease and chronic infections.

By Leigh MacMillan
February 20, 2020

Transporter mutation alters cell energy

A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered.

By Leigh MacMillan
Brain image
November 14, 2019

Blueprint for treating epilepsy

Structural details of a protein that is essential to normal brain function could improve treatments for epilepsy and other seizure disorders.

By Bill Snyder
July 24, 2019

Defective transporter linked to autism

A first-of-its-kind mouse model may help reveal mechanistic underpinnings for the altered behaviors of autism spectrum disorder.

By Bill Snyder
May 29, 2019

Study details regulation of a multi-drug transporter

P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.
By Leigh MacMillan
August 16, 2018

A new target for lung cancer

Vanderbilt researchers have identified a new vulnerability in lung cancer — the transporter protein xCT — that may a therapeutic target for the disease.
By Leigh MacMillan
July 19, 2018

Fueling the MATE transporter

Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.
By Sanjay Mishra
October 23, 2014

New view of transporter dynamics

New insights to the workings of a protein that moves neurotransmitters across the nerve cell membrane could aid the design of more effective antidepressants.
By Bill Snyder
October 14, 2014

Neuronal culprit in genetic disease

A particular neuronal cell population is involved in the pathogenesis of a rare neurological disorder, Vanderbilt researchers have discovered.
By Leigh MacMillan
April 24, 2014

New view of neurotransmitter transport

Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders.
By Leigh MacMillan
November 7, 2013

Neurotransmitter’s role in bone balance

Removal of the neurotransmitter norepinephrine from the space outside cells plays an important role in the regulation of bone remodeling.
By Leigh MacMillan