tumor suppressor

Frank Mason, PhD, left, Kimryn Rathmell, MD, PhD, and their colleagues have identified an early event in the development of cancer, one that could lead to new ways to prevent it. (photo by Erin O. Smith)
September 20, 2023

VUMC study reveals critical first steps to cancer

A new study by Vanderbilt researchers provides a remarkably detailed view of the earliest events leading to the development of cancer, and of potential new ways to prevent it.

By Bill Snyder
January 9, 2023

Novel lung cancer biomarker

Autoantibodies against the p53 tumor suppressor protein may be a novel biomarker for identifying people, especially African Americans, at high risk for lung cancer.

By Leigh MacMillan
The team studying tumor suppressor protein p53 includes, from left, Jennifer Pietenpol, PhD, and Lindsay Redman-Rivera.
September 2, 2021

Discovery offers insight for development of cancer therapies targeting mutant p53

Vanderbilt researchers have discovered that aneuploidy (an abnormal number of chromosomes) drives malignant phenotypes in cells expressing mutant p53, a tumor suppressor protein that is mutated in more than half of all human cancers.

By Bill Snyder
October 29, 2020

New markers of colorectal cancer risk

Vanderbilt epidemiologists identified new markers for colorectal cancer risk and characterized a previously unidentified tumor suppressor that regulates overall tumor volume in vivo.

By Sarah E. Glass
January 19, 2017

COX-2 ‘conjugate’ may slow growth of some tumors: study

More than a decade after the anti-inflammatory drugs Vioxx and Bextra were pulled from the market because of a heightened risk of heart attack and stroke in some patients, COX-2 inhibitors may be on the verge of a comeback, this time as anti-cancer agents.

By Bill Snyder
October 23, 2012

Stomach bug alters tumor suppressor

The stomach bug Helicobacter pylori increases forms of a protein that promote tumor development, perhaps explaining how it elevates risk for gastric cancer.

By Leigh MacMillan
January 25, 2012

Protein repairs esophageal DNA damage

A protein involved in repairing DNA damage associated with gastric reflux may play a tumor suppressor role in the esophagus and could represent a target for therapies to combat esophageal cancer.
By VUMC News and Communications