December 7, 2007

‘Mighty mouse’ maker set for Discovery Lecture

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‘Mighty mouse’ maker set for Discovery Lecture

Richard Hanson, Ph.D., one of the makers of the recently reported “mighty mouse” — a genetically engineered mouse that outruns, out-eats and outlives other mice — will deliver the next Discovery Lecture.

Hanson, the Leonard & Jean Skeggs Professor of Biochemistry at Case Western Reserve University School of Medicine in Cleveland, and colleagues recently reported their development of mice that over-express the enzyme phosphoenolpyruvate carboxykinase, or PEPCK, in skeletal muscle.

Hanson's research has probed the factors involved in regulating the expression of the gene encoding PEPCK. He will discuss his work on this enzyme in his talk, "Phosphoenolpyruvate Carboxykinase: The Joy of Thinking Outside the Box,” on Thursday, Dec. 13, at 4 p.m., in 208 Light Hall, with a reception to follow in the lobby.

This Discovery Lecture is sponsored by the Department of Biochemistry, the Division of Nephrol-ogy and the Office for Diversity in Medical Education.

For a complete schedule of the Discovery Lecture Series and archived video of previous lectures, go to