Genetics & Genomics

June 3, 2021

Predictive model identifies patients for genetic testing

Patients who, perhaps unbeknownst to their health care providers, are in need of genetic testing for rare undiagnosed diseases can be identified en masse based on routine information in electronic health records (EHRs), a research team reported June 3 in the journal Nature Medicine.

By Paul Govern
June 3, 2021

Patient of Monroe Carell Jr. Children’s Hospital at Vanderbilt first in world to receive new investigational gene editing therapy

A 9-year-old patient of Monroe Carell Jr. Children’s Hospital at Vanderbilt is the first in the world to receive an investigational gene editing therapy for Methylmalonic Acidemia (MMA), a rare genetic disorder diagnosed at birth.

By Christina Echegaray
May 13, 2021

People at high genetic risk for colorectal cancer benefit more from lifestyle changes

People with a high polygenic risk score for colorectal cancer could benefit more at preventing the disease by leading healthy lifestyles than those at lower genetic risk, according to a study by Vanderbilt researchers published in the April issue of The American Journal of Clinical Nutrition.

By Tom Wilemon
April 29, 2021

Genetic ancestry and hypertension risk

Racial disparities in hypertension risk are due in part to genetic differences between ancestries, Vanderbilt investigators find in a study of participants in the Million Veteran Program.

By Bill Snyder
March 15, 2021

Roden honored with Oscar B. Hunter Career Award in Therapeutics

Dan Roden, MD, Senior Vice President for Personalized Medicine at Vanderbilt University Medical Center, received the Oscar B. Hunter Career Award in Therapeutics last week at the virtual annual meeting of the American Society for Clinical Pharmacology and Therapeutics.

By Leigh MacMillan
March 11, 2021

Genotype looms large in risk for post-op arrhythmia

Postoperative atrial fibrillation (PoAF), a form of arrhythmia, complicates 20-40% of cardiac surgical procedures and 10–20% of non-cardiac thoracic operations, cropping up two to four days after surgery to pose risk of stroke, heart attack, mortality, longer hospital stays and greater cost.

By Paul Govern
March 9, 2021

Study incorporates genetics with smoking history to identify high-risk smokers for lung cancer screening

A study by Vanderbilt researchers that analyzed both smoking history and genetic risk variants for lung cancer supports modifying current guidelines to include additional smokers for lung cancer screening.
By Tom Wilemon
January 21, 2021

Study finds genetic clues to pneumonia risk and COVID-19 disparities

Researchers at Vanderbilt University Medical Center and colleagues have identified genetic factors that increase the risk for developing pneumonia and its severe, life-threatening consequences.
By Bill Snyder
October 22, 2020

New tool to probe genetic mechanisms of disease

Vanderbilt Genetics Institute investigators have added a new method to the computational genetics toolbox. Their approach, described in the journal Nature Genetics, integrates vast genomics datasets to predict gene expression and facilitate discovery of genetic mechanisms underlying human diseases.
By Leigh MacMillan
October 1, 2020

Genes spell penicillin allergy risk

Studies using large DNA biobanks revealed genetic variants associated with penicillin allergy, the most common type of drug-induced allergic reaction.
By Paul Govern
September 17, 2020

Grant from Google to support COVID gene expression study

Vanderbilt University Medical Center and the University of North Carolina (UNC) at Chapel Hill have been awarded $500,000 by Google’s philanthropy, Google.org, to study how COVID-19 alters gene expression in some people in ways that may be linked to their risk of severe illness and death.
By Bill Snyder
September 10, 2020

Award supports integration of genomic data, electronic health records

Eric Gamazon, PhD, assistant professor of Medicine, has been awarded a $1.5 million grant from the National Human Genome Research Institute, part of the National Institutes of Health (NIH), to develop novel computational tools that integrate functional genomic data and electronic health records.
By Leigh MacMillan
September 7, 2020

Possible key to COVID-19 infectivity

New findings demonstrate how genetic variations in the receptor that binds SARS-CoV-2 impact virus recognition and infectivity and offer insights to COVID-19 susceptibility and treatment.
By Sarah E. Glass
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