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breast cancer Archives

Clinical trial shows efficacy for atezolizumab combined with carboplatin

Dec. 15, 2023—by Tom Wilemon Immunotherapy in combination with chemotherapy has become an important therapeutic treatment option in some patients with metastatic breast cancer. Which patients will benefit the most, however, remains unclear; current biomarkers such as PD-L1 that are used to predict response are mediocre at best. Vanderbilt researchers led a clinical trial combining atezolizumab, an...

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Vulnerability found in immunotherapy-resistant triple-negative breast cancer

Oct. 4, 2023—Vanderbilt researchers have discovered a druggable target on natural killer cells that could potentially trigger a therapeutic response in patients with immunotherapy-resistant, triple-negative breast cancer.

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International workgroup of geneticists issues CHEK2 guidelines

Jul. 26, 2023—International workgroup issues additional guidance on how to manage patients who carry inherited CHEK2 gene mutations that put them at a higher risk for cancer.

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An image of cancer treatment response

Jun. 8, 2023—An MRI method developed by Vanderbilt researchers uses imaging data to derive cell size and could be added to clinical practice for better monitoring of breast cancer treatment response.

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Nicole Kidman and Keith Urban gift supports breast cancer clinical trials at Vanderbilt-Ingram Cancer Center

Mar. 7, 2023—Nicole Kidman and Keith Urban have made a generous financial gift to Vanderbilt-Ingram Cancer Center in support of clinical trials for new and better therapies for breast cancer.

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Breast cancer genetics: new insights

Feb. 16, 2023—Largest genetic study of breast cancer to date identifies 222 genetic risk loci, 137 genes and multiple signaling pathways associated with risk, providing important new insights.

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Surgery for hereditary breast cancer

Nov. 17, 2022—Similar rates of bilateral mastectomy in women with inherited mutations in high- and moderate-penetrance genes raises concerns about possible overtreatment of some patients, Vanderbilt researchers report.

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Cell-free breast cancer “biopsy”

Aug. 11, 2022—The circulating DNA that tumors release is a reliable metric of tumor genomics and can be used to monitor molecular changes in metastatic breast cancer.

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Five-year, multi-site trial to assess lymphedema prevention concludes

Jun. 20, 2022—Lymphedema study results could be a game-changer for breast cancer patients and survivors. The Vanderbilt-led trial found that patients with early detection who used L-Dex with additional intervention were less likely to progress to chronic lymphedema than patients monitored with a tape measure receiving the same intervention. 

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Breast cancer biomarkers of response

Jun. 16, 2022—Vanderbilt researchers have identified blood-based biomarkers associated with complete responses to neoadjuvant chemotherapy in patients with breast cancer.

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New Clinician Spotlight: Kelly Hewitt

Dec. 8, 2021—Kelly Hewitt, MD, recently joined the Division of Surgical Oncology after being recruited from St. Charles Health System in Bend, Oregon, where she served as medical director of the Breast Program.

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‘Multi-omics’ reveals treatment option for breast cancer subtype

Nov. 18, 2021—  by Bill Snyder In a multidisciplinary collaboration, researchers at Vanderbilt University Medical Center and the University of Miami Miller School of Medicine have identified a subtype of triple-negative breast cancer (TNBC) that appears to be able to escape detection by the immune system and evade immunotherapy. Their report, published Nov. 1 in the journal...

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