Circulation (journal) Archive — Page 1 of 2

Three researchers stand in a laboratory between shelves of boxes, bottles, pipettes, and other scientific equipment. From left, Dan Roden, MD, Andrew Glazer, PhD, and Lorena Harvey, PhD.
October 21, 2026

Vanderbilt Health-led team maps gene variants that can cause sudden death

The research may enable more precise diagnosis and treatment of a disorder that causes sudden death in about 3,500 people in the United States each year.

Medical illustration showing two kidneys and their major blood vessels, with the kidney on the right cut open to reveal internal structures.
October 5, 2026

Opportunities to advance precision kidney medicine for women: Vanderbilt Health-led scientific statement

The scientific statement suggests improving women’s kidney care by recognizing how women’s unique biology and social factors affect kidney health and designing research that includes sex-specific analyses of kidney function and chronic kidney disease medications.

Close-up of a person using a glucometer to measure blood glucose from a fingertip, with a lancing device and small container nearby.
October 5, 2026

Human trial: Popular diabetes drug shown to lower inflammation, which may protect the heart

Individuals taking the drug saw a significant drop in inflammatory cell clumps within just two weeks, and the reduction grew even stronger by week 12.

Side-by-side cutaway illustrations of the heart showing a narrowed, calcified aortic valve on the left and a healthy open aortic valve on the right, with enlarged valve views below.
July 20, 2026

Vanderbilt Health-led registry identifies gaps, aims to improve outcomes for aortic stenosis patients

The registry is the first to track data and evaluate the quality of upstream care processes before valve replacement for patients with aortic stenosis — the most common type of heart valve disease in developed nations.

Stylized 3D anatomical illustration of a human upper body showing the glowing heart, major blood vessels, and an extensive network of branching vessels against a black background.
May 11, 2026

Multi-organ metabolite ‘signature’ signals increased heart failure risk

A multi-institutional group has identified a “signature” of metabolic molecules associated with exercise-induced physiologic deficits that, when released into the bloodstream, signal heightened heart failure risk.

Two fluorescent microscopy images of artery cross-sections: a healthy mouse artery on the left with predominantly green smooth muscle cells, and an atherosclerotic mouse artery on the right with green cells and prominent red-purple fluorescence within the plaque indicating DNA damage.
April 30, 2024

Atherosclerosis is a tumor-like disease: study

An anticancer drug blunted atherosclerosis progression — and even made plaques shrink — in a mouse model of the disease, opening new opportunities for preventing and treating this leading cause of death.