Department of Medicine

Study suggests new threshold for diagnosing PAH

Doctors diagnosing pulmonary arterial hypertension (PAH) — elevated pulmonary pressure due to an issue in the small vessels of the lung — rely on a hemodynamic threshold set in the early 1970s to determine whether patients would be candidates for pulmonary vasodilator therapy.

A step toward cancer prevention

A computational technique that combines the effect of multiple genomic variants has the potential to identify high-risk individuals for cancer prevention.

Appendix cancer survival in young patients varies by race: study

The first study of appendiceal cancer patterns and survival by race/ethnicity among patients younger than 50 in the U.S. showed survival disparities.

Heart patient Ronnie Kreis is monitored by VHVI doctors while he’s at his home in East Tennessee.

Device allows VHVI doctors to monitor heart patients remotely

In 2018, Ronnie Kreis began to develop severe heart failure. After being hospitalized multiple times that year near his home in Oliver Springs in East Tennessee, he was told that nothing else could be done.

Marcela Brissova, PhD, and MD/PhD student John “Jack” Walker are part of the research team that developed a pseudoislet system for integrated studies of human islet function.

Pseudoislet system expected to advance pancreas and diabetes research

The multicellular, 3-D structure of human pancreatic islets — the areas of the pancreas containing hormone-producing or endocrine cells — has presented challenges to researchers as they study and manipulate these cells’ function, but Vanderbilt University Medical Center researchers have now developed a pseudoislet system that allows for much easier study of islet function.

Protein study may be key to treating fibrotic diseases

A protein linked to amyotrophic lateral sclerosis (ALS), a progressive neurological disease that causes muscle weakness, may be a key to treating fibrotic disease of the kidneys and other organs, researchers at Vanderbilt University Medical Center reported recently.

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