The research characterizes the molecular “cargo” of circulating extracellular vesicles in obesity and links the findings to human genetic approaches to identify potential therapeutic targets for metabolic disease.

The analysis of genetic sequencing data from more than 34,000 people over a 17-year period by researchers at VUMC was published in eClinicalMedicine.

The children were born in Turkey with a smaller-than-normal head size, cataracts, severe developmental delay, intellectual disability and epilepsy.

The research is another step toward development of targeted therapies aimed at reducing the incidence and medical burden of this common condition.

Severe obesity — a condition of being 100 pounds or more overweight — has doubled in the United States over the past two decades to 9.2%, with the greatest increases among women and Latino populations.

The Vanderbilt Genetics Institute is the intellectual hub for genomics research at Vanderbilt University Medical Center and Vanderbilt University.

A new study will use innovative methods developed at VUMC to look for drugs already approved for other uses that could potentially be repurposed to treat Alzheimer's.