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inflammation Archives

Reducing obesity-related inflammation

Mar. 24, 2022—A treatment that increases levels of lipid signaling molecules reduced adipose tissue inflammation in obese adults, suggesting this pathway may be a valuable target for modulating fat and systemic inflammation.

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Study identifies molecular trigger of severe injury-induced inflammatory response

Jan. 19, 2022—Vanderbilt researchers have discovered that early inappropriate activation of the enzyme plasmin caused by severe injury is a trigger of systemic inflammatory response syndrome and resulting organ failure.

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The role of integrins in kidney “integrity”

Jan. 13, 2022—Receptors called integrins play a critical role in maintaining the structure of the kidney, Vanderbilt researchers have discovered.

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Vitamin D impact on disease biomarkers

Aug. 10, 2021—In a randomized controlled trial, vitamin D supplementation did not improve biomarkers for cardiovascular and metabolic disease.

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COVID-19 complication underdiagnosed

Jun. 17, 2021—A mysterious inflammatory syndrome linked to COVID-19 infection and first identified in children also occurs in adults, Vanderbilt researchers report.

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Inflammation in genetic epilepsy

Jan. 21, 2021—Brain inflammation links genetic and acquired epilepsy — providing new clues about epilepsy development and pointing to potential treatments.

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Study details early events of inflammatory response

Dec. 10, 2020—Vanderbilt University Medical Center investigators have identified a key molecular player in the early events of the inflammatory response to infection. The findings suggest new therapeutic possibilities for enhancing the inflammatory response to protect against pathogens and for blocking inflammation gone awry in diseases like arthritis and atherosclerosis.

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Salt, immune cells and hypertension

Aug. 20, 2020—Excess dietary salt activates immune cells to induce inflammation and hypertension, supporting current recommendations for low sodium consumption.

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Risk marker for repeat sinus surgery

Aug. 11, 2020—An inflammatory factor in mucus could be a biomarker of treatment-resistant chronic sinusitis used to determine which patients are at risk for repeat sinus surgery.

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New tools to study bioactive lipids

Jul. 14, 2020—Vanderbilt researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction.

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“Nur” target may aid arthritis treatment

Jul. 13, 2020—Vanderbilt immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells.

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A new contributor to atherosclerosis

Jan. 27, 2020—Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis.

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