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Jonathan Mosley Archives

A biomarker for early Type 2 diabetes

Feb. 1, 2024—Genetic analyses suggest that branched chain amino acids may be a sensitive biomarker of early or subclinical Type 2 diabetes and could be used to identify risk and implement preventive measures.

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Polygenic “scores” may improve cancer screening

Oct. 31, 2023—Accounting for genetic variability in biomarkers not associated with cancer risk could avoid unnecessary diagnostic procedures, Vanderbilt researchers found.

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Study evaluates polygenic risk score for prostate cancer risk prediction

Mar. 16, 2023—A Vanderbilt study found that prostate cancer polygenic risk score has limited utility for enhancing prostate cancer screening.

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Genotype-specific blood counts

Aug. 11, 2022—Vanderbilt researchers report genotype-specific reference ranges to improve interpretation of laboratory blood results in African Americans with a common gene variant that lowers white blood cell counts.

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BMI genetics influence heart function

Jun. 16, 2022—Vanderbilt researchers have discovered that a genetic predisposition to elevated body mass index increases the risk of diastolic dysfunction — a cardiac condition that can lead to heart failure.

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Two VUMC papers named among genomic medicine’s top 10

Dec. 16, 2021—Vanderbilt researchers wrote two of the “top 10” papers representing key advances in genomic medicine published between September 2020 and August 2021.

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For more precise drug treatments, ‘squeeze’ the genome: study finds

Jul. 22, 2021—Large-scale studies will be required to identify the complexity of genetic variations that affect how patients respond to a given drug and whether they will have side effects, according to researchers at Vanderbilt University Medical Center.

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Gene variant linked to unnecessary bone marrow biopsies in African Americans

Jun. 28, 2021—A gene variant that lowers white blood cell levels and is common in individuals with African ancestry contributes to unnecessary bone marrow biopsies, according to a study published June 28 in JAMA Internal Medicine.

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Study finds certain genetic test not useful in predicting heart disease risk

Feb. 27, 2020—A Polygenic Risk Score — a genetic assessment that doctors have hoped could predict coronary heart disease (CHD) in patients — has been found not to be a useful predictive biomarker for disease risk.

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Research bolsters thyroid function, atrial fibrillation link

Jan. 31, 2019—A study by researchers at Vanderbilt University Medical Center has strengthened the link between thyroid function and atrial fibrillation (AF), an irregular heart rhythm that increases the risk of stroke and other heart-related complications.

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Team’s study reveals hidden lives of medical biomarkers

Oct. 11, 2018—What do medical biomarkers do on evenings and weekends, when they might be considered off the clock?

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Researchers chart new informatics path in tracking disease risk

Feb. 23, 2017—In a study in Circulation: Cardiovascular Genetics, Vanderbilt University’s Jonathan Mosley, M.D., Ph.D., and colleagues use genetic correlation to hitch together two unrelated sets of data, one from a longstanding epidemiological cohort and the other from electronic health records.

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