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Journal of Biological Chemistry Archives

A key to calcium signaling

Feb. 11, 2020—Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles.

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A new contributor to atherosclerosis

Jan. 27, 2020—Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis.

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A new anti-seizure target?

Dec. 12, 2019—Vanderbilt neurologists have identified a protein modification that could be targeted to reduce neuronal excitability in epilepsy.

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How nerves may lose their insulation

Aug. 22, 2019—Vanderbilt’s Bruce Carter and colleagues have discovered how genetic changes in the protein PMP22 may contribute to a disease of peripheral nerves.

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Steroid binding to metabolic enzyme

Jun. 12, 2019—Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.

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Scavengers “protect” HDL

Jun. 29, 2018—Jun. 29, 2018—Lipid molecules that bind to HDL can modify its function — and blocking that modification can protect HDL and potentially lower the risk of atherosclerosis and heart disease.

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Versatile C. difficile blocker

Jan. 26, 2018—New research reveals a unique mechanism of C. difficile toxin neutralization by a monoclonal antibody, suggesting new therapeutic approaches.

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A cataract-heart connection

Jan. 25, 2018—Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease.

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A spicy finding

Jan. 16, 2018—Vanderbilt researchers have discovered that curcumin — the active ingredient in the spice turmeric — needs to be metabolically activated to exert anti-inflammatory effects.

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Forming memories through CaMKII

Dec. 19, 2017—Vanderbilt researchers have identified an interaction between two proteins that play a role in learning and memory.

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DNA damage repair: molecular insights

Dec. 5, 2017—Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.

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Altered metabolism and disease

Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

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Vanderbilt University School of Medicine entrance

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