Journal of Biological Chemistry

The 2023 Aspirnaut summer research interns, flanked by the program’s co-founders, Julie Hudson, MD, left, and Billy Hudson, PhD, back row, right. (photo by Susan Urmy)
October 12, 2023

Student researchers at VUMC earn accolades for their report

A research paper co-authored by 23 high school and undergraduate students participating in Vanderbilt University Medical Center’s Aspirnaut summer research program has been selected as one of the “Editor’s Picks” by the Journal of Biological Chemistry.

By Bill Snyder
July 11, 2022

A speedier treatment for depression?

Vanderbilt researchers used a computer-based search to identify a compound with promise as a new, mechanistically distinct and rapid-acting therapy for major depressive disorder.

By Paul Govern
September 7, 2021

Regulators of fat cell metabolism

Vanderbilt researchers have discovered new details of the regulation of fat cell metabolism, findings that are important for combating obesity.

By Leigh MacMillan
August 19, 2021

Potential protection from atherosclerosis

Vanderbilt researchers have discovered a potential way to reduce atherosclerosis: blocking the modification of an HDL-associated enzyme by reactive molecules called isolevuglandins.

By Bill Snyder
April 15, 2021

New insights into kidney development

Integrin-linked kinase, a central component of a complex that coordinates cell signaling involved in migration, proliferation and cell death, plays a role in kidney development and epithelial cell function.

By Bill Snyder
April 15, 2021

Arrhythmia culprit: supertrafficking ion channel

Charles Sanders, PhD, and colleagues show how a “supertrafficking” mutant potassium channel contributes to heart rhythm abnormalities.

By Leigh MacMillan
July 14, 2020

New tools to study bioactive lipids

Vanderbilt researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction.
By Leigh MacMillan
June 9, 2020

Staph’s activation of blood clotting

Staph bacteria may change the factor they use to activate blood clotting — to evade the immune response — a new study suggests.
By Leigh MacMillan
February 11, 2020

A key to calcium signaling

Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles.
By Sanjay Mishra
January 27, 2020

A new contributor to atherosclerosis

Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis.
By Leigh MacMillan
December 12, 2019

A new anti-seizure target?

Vanderbilt neurologists have identified a protein modification that could be targeted to reduce neuronal excitability in epilepsy.
By Leigh MacMillan
August 22, 2019

How nerves may lose their insulation

Vanderbilt’s Bruce Carter and colleagues have discovered how genetic changes in the protein PMP22 may contribute to a disease of peripheral nerves.
By Bill Snyder
June 12, 2019

Steroid binding to metabolic enzyme

Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.
By Bill Snyder
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