Journal of Biological Chemistry Archives
A speedier treatment for depression?
Jul. 11, 2022—Vanderbilt researchers used a computer-based search to identify a compound with promise as a new, mechanistically distinct and rapid-acting therapy for major depressive disorder.
Regulators of fat cell metabolism
Sep. 7, 2021—Vanderbilt researchers have discovered new details of the regulation of fat cell metabolism, findings that are important for combating obesity.
Potential protection from atherosclerosis
Aug. 19, 2021—Vanderbilt researchers have discovered a potential way to reduce atherosclerosis: blocking the modification of an HDL-associated enzyme by reactive molecules called isolevuglandins.
New insights into kidney development
Apr. 15, 2021—Integrin-linked kinase, a central component of a complex that coordinates cell signaling involved in migration, proliferation and cell death, plays a role in kidney development and epithelial cell function.
Arrhythmia culprit: supertrafficking ion channel
Apr. 15, 2021—Charles Sanders, PhD, and colleagues show how a “supertrafficking” mutant potassium channel contributes to heart rhythm abnormalities.
New tools to study bioactive lipids
Jul. 14, 2020—Vanderbilt researchers have identified and characterized inhibitors of an enzyme that synthesizes lipid signaling molecules with roles in energy balance, inflammation and addiction.
Staph’s activation of blood clotting
Jun. 9, 2020—Staph bacteria may change the factor they use to activate blood clotting — to evade the immune response — a new study suggests.
A key to calcium signaling
Feb. 11, 2020—Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles.
A new contributor to atherosclerosis
Jan. 27, 2020—Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis.
A new anti-seizure target?
Dec. 12, 2019—Vanderbilt neurologists have identified a protein modification that could be targeted to reduce neuronal excitability in epilepsy.
How nerves may lose their insulation
Aug. 22, 2019—Vanderbilt’s Bruce Carter and colleagues have discovered how genetic changes in the protein PMP22 may contribute to a disease of peripheral nerves.
Steroid binding to metabolic enzyme
Jun. 12, 2019—Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.