Journal of Clinical Investigation

October 22, 2015

Study sheds light on side effects of COX-2 drugs

A team of Vanderbilt University Medical Center scientists are closer to understanding why COX-2 inhibitors — drugs that relieve arthritis pain and inflammation without the gastrointestinal side effects of other painkillers — cause heart problems in some patients.

Now

By Bill Snyder
August 13, 2015

VUMC study shifts thinking on how bone fractures heal

New findings show that fibrin, a protein that was thought to play a key role in fracture healing, is not required, shifting understanding of how fractures heal.

By Leigh MacMillan
July 23, 2015

Study explores protein’s role in inflammation-associated cancer

An antioxidant protein may protect against colon cancer that develops in patients with inflammatory bowel disease, suggesting new strategies for reducing colon cancer risk in these patients.

By Leigh MacMillan
June 11, 2015

Study: Why one kidney can work as well as two

Vanderbilt University researchers have come closer to solving a mystery that has puzzled scientists for more than a century: after the loss of one kidney, what causes the growth of the remaining kidney to take up the slack?

By Bill Snyder
HIV cell
May 21, 2015

‘Redesigned’ antibodies may control HIV: study

With the help of a computer program called “Rosetta,” researchers at Vanderbilt University have “redesigned” an antibody that has increased potency and can neutralize more strains of the AIDS-causing human immunodeficiency virus (HIV) than can any known natural antibody.

By Bill Snyder
April 30, 2015

Team tracks how kidney responds to blood pressure meds

Changes in the kidney can limit the blood pressure-lowering effects of thiazide diuretics, a new study reports.

By Leigh MacMillan
April 2, 2015

Gene variant, environment can boost RSV severity

A particular genetic mutation combined with an urban environment increases the risk of severe disease in children infected with respiratory syncytial virus (RSV), an international team of investigators has found.
By Leigh MacMillan
February 12, 2015

VU study explores inflammation, hypertension link

The evidence is increasing: the immune system and inflammation are key contributors to high blood pressure.
By Bill Snyder
November 20, 2014

Gene mutation linked to breast cancer therapy resistance

A group of Vanderbilt-led investigators has identified a new gene mutation that may explain why some breast cancer patients do not respond to anti-hormone therapy.
By VUMC News and Communications
July 24, 2014

Team spots trigger for rare diarrheal disease in infants

Researchers at Vanderbilt University, the University of Arizona and Phoenix Children’s Hospital have discovered what triggers a rare but devastating diarrheal disease in newborns that is fatal without intravenous feeding or intestinal transplant.
By Bill Snyder
July 17, 2014

Study examines therapeutic bacteria’s ability to prevent obesity

Engineered bacteria that produce a therapeutic compound in the gut prevent obesity in mice, Vanderbilt University investigators have discovered.
By Leigh MacMillan
July 10, 2014

Molecular ‘chat’ holds kidney fibrosis clues

A novel molecular “conversation” regulates kidney fibrosis – the final result of end-stage chronic kidney disease – suggesting new treatment options for this currently irreversible process.
By Leigh MacMillan
April 10, 2014

Study tracks new lung cancer drug target

Researchers at Vanderbilt University have identified a potential new drug target in subtypes of lung cancer that are difficult to treat.
By Bill Snyder