Journal of Clinical Investigation

Studies shed new light on breast cancer development

Rebecca Cook, Ph.D., assistant professor of Cancer Biology, has spent her life trying to understand what makes things grow, from seedlings in soil to tumor cells in the body.

Researchers identify novel biomarker for diabetes risk

Researchers at the Vanderbilt Heart and Vascular Institute and Massachusetts General Hospital have identified a biomarker that can predict diabetes risk up to 10 years before onset of the disease.

Study tracks skin salt’s role in blood pressure control

Clinical pharmacologist Jens Titze, M.D., and his colleagues have identified a new cast of cells and molecules that function in the skin to control sodium balance and blood pressure.

Study lays groundwork for rational T cell vaccine design

Vanderbilt University investigators have developed a new strategy for identifying the “bits” of a pathogen that spark a protective immune response.

Breast cancer study explores therapy to slow recurrence

Many patients with triple-negative breast cancer (TNBC) have recurrence of their disease after an initial response to chemotherapy because the cancer cells have become resistant to treatment. TNBC has a lower survival rate because of this pattern of resistance and there are no targeted agents to treat this form of breast cancer.

Linking oxygen, iron and red blood cells

The HIF oxygen-sensing pathway and its responses to low oxygen may be targeted for treatments of anemia and disorders of iron balance.

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