Nature Communications (journal)

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Study of severe drug reactions finds skin cells activate their own assassins

Single-cell analysis reveals the inner workings of the life-threatening adverse drug reactions Stevens-Johnson syndrome and toxic epidermal necrolysis.

Distant relatedness in biobanks harnessed to identify undiagnosed genetic disease

VUMC researchers have developed a genetic method that clusters distantly related people to find rare variants that were present in a common ancestor.

Bacterial metabolism plays role in staph antibiotic tolerance

Staph is a leading bacterial cause of death from bloodstream, bone and joint infections, in part because of high rates of antibiotic treatment failure.

Epigenetic change to DNA associated with cancer risk in ‘multi-omics’ study

The new study identifies 4,248 CpG sites associated with the risk of seven different types of cancer: breast, colorectal, renal cell, lung, ovarian, prostate and testicular germ cell cancers.

Three-dimensional imaging of kidney tubules (yellow and green noodle-like structures) under low potassium conditions, which puts the kidney into a state of metabolic overdrive and causes cardiovascular problems.

Low potassium ‘turns on’ kidney proximal tubule: study

A kidney protein that responds to low levels of blood potassium — which can cause high blood pressure and cardiovascular problems — may be a target for new therapeutics.

Photo caption: Jonathan Mosley, MD, PhD, left, Scott Borinstein, MD, PhD, John Shelley, and Vivian Kawai, MD, MPH, are studying how genetic variation not related to disease affects clinical decisions. (photo by Susan Urmy)

Genetic variation associated with low white blood cell count impacts clinical decisions

People whose white blood cell levels are near the edge of the “healthy” reference range will hit a clinical decision point that has consequences such as diagnostic procedures and altered treatments.

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