Nature (journal)

James Crowe Jr., MD, and colleagues are exploring how the body’s immune system gears up to fight off infection.
October 13, 2020

COVID-19 long-acting antibodies discovered by Vanderbilt University Medical Center move to phase 3 clinical trials

AstraZeneca is advancing into phase 3 clinical trials with an investigational COVID-19 therapy of two long-acting antibodies discovered by Vanderbilt University Medical Center and optimized by AstraZeneca.

By Bill Snyder
October 31, 2019

Vanderbilt investigators lead effort to create map of the human kidney

Short of mandating universal diabetes treatment, regular exercise and low-calorie diets, little can be done to stem the rising tide of kidney failure — unless scientists can figure out why exactly the kidney’s filtration units, the glomeruli, stop working.

By Bill Snyder
June 18, 2019

Study identifies critical regulator of tumor-specific T cell differentiation

A study published June 17 in Nature offers clues as to why blocking inhibitory receptors on tumor-infiltrating T cells may not always work

By Tom Wilemon
James Crowe Jr., MD, and colleagues are exploring how the body’s immune system gears up to fight off infection.
February 13, 2019

Researchers push forward frontiers of vaccine science

Using sophisticated gene sequencing and computing techniques, researchers at Vanderbilt University Medical Center and the San Diego Supercomputer Center have achieved a first-of-its-kind glimpse into how the body’s immune system gears up to fight off infection.

By Bill Snyder
May 17, 2018

Alphavirus “Achilles heel”

Targeting the protein that mosquito-borne viruses use to enter cells could be a strategy for preventing infection by multiple emerging viruses.

By Bill Snyder
bright yellow water pump
March 16, 2017

Study catches ‘notorious’ drug pump in action

Researchers at Vanderbilt University Medical Center (VUMC) have mapped the conformational changes that occur in a protein “notorious” for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous system.

By Bill Snyder
November 7, 2016

Early study finds antibody that ‘neutralizes’ Zika virus

Researchers at Vanderbilt University Medical Center and Washington University School of Medicine in St. Louis have isolated a human monoclonal antibody that in a mouse model “markedly reduced” infection by the Zika virus.
By Bill Snyder
August 11, 2016

Study explores low oxygen’s impact on antibody quality

Hypoxia (lack of enough oxygen) is bad for the body as a whole, but in the neighborhood where infection-fighting antibodies arise, may be important for keeping proper order.
By Bill Snyder
January 22, 2015

New signaling pathway provides clues to obesity

A Vanderbilt University-led research team has discovered a molecular “rheostat” in the brain’s appetite control center that may provide new insights into obesity, which is at epidemic levels in this country.
By Bill Snyder
July 24, 2014

Colon cancer’s protein signatures identified

A Vanderbilt University-led research team has identified protein “signatures” of genetic mutations that drive colorectal cancer, the nation’s second leading cause of cancer deaths after lung cancer.
By Bill Snyder
July 9, 2014

Study finds ‘hot’ frogs fight off fungal pathogen

Simple heat treatments may give the frog immune system a boost and help it fight off a deadly fungal pathogen, according to a new study published July 10 in the journal Nature.
By Leigh MacMillan
January 26, 2012

Investigators seek clues to resistance to melanoma drug

Investigators at Vanderbilt-Ingram Cancer Center and several other centers may be one step closer to finding out why some melanoma patients relapse after treatment with a promising new drug.
By VUMC News and Communications