New England Journal of Medicine

February 28, 2022

Study finds azithromycin use during RSV not useful in preventing recurrent wheezing, may cause harm

Vanderbilt research on the impact of the antibiotic azithromycin during severe respiratory syncytial virus (RSV) bronchiolitis overwhelmingly support current national bronchiolitis guidelines, which recommend against antibiotics during acute bronchiolitis due to lack of effect on the acute illness.

By Jessica Pasley
December 8, 2021

International study supports dupilumab for treatment of moderate-to-severe asthma in children

In a late-stage clinical trial, the biologic agent dupilumab reduced the rate of severe asthma attacks and improved lung function and asthma control for children ages 6 to 11 with moderate-to-severe asthma, offering a new option to these patients.

By Leigh MacMillan
May 20, 2021

VUMC is pacesetter for national aspirin study

According to an innovative large-scale clinical trial reported last week in the New England Journal of Medicine, a single daily baby aspirin (81 mg) or a single daily adult aspirin (325 mg) are equally safe and effective for prevention of adverse cardiovascular events for patients with established atherosclerotic cardiovascular disease.

By Paul Govern
April 22, 2021

A young doctor wrote of a life-or-death moment caring for a patient. The New England Journal of Medicine published it as a graphic novel.

A terrifying tale from her first weekend on call.

By Emily Stembridge
Christopher Hughes, MD, left, Pratik Pandharipande, MD, MSCI, and colleagues are studying two drugs recommended for patients receiving mechanical ventilation in the ICU.
February 2, 2021

Study finds recommended ICU sedatives equally safe, effective

Sedative medications used in intensive care are associated with increased delirium, which is in turn connected with higher medical costs and greater risk of death and ICU-related dementia.

By Paul Govern
October 5, 2020

Treating appendicitis with antibiotics instead of surgery may be good option for some, but not all, patients

Antibiotics instead of surgery may be a good choice for some, but not all, patients with appendicitis, according to results from a study reported today in the New England Journal of Medicine.

By Nancy Humphrey
July 22, 2020

New data offer insights on COVID treatments for people with cancer

Newly released data on treatment outcomes of people with cancer diagnosed with COVID-19 reveal a racial disparity in access to Remdesivir, an antiviral drug that has been shown to shorten hospital stays, and increased mortality associated with dexamethasone, a steroid that has had the opposite effect in the general patient population.
By Tom Wilemon
July 14, 2020

VUMC studies provide key positive results for COVID-19 vaccine in early-stage clinical trial

An experimental coronavirus vaccine stimulated robust immune responses against SARS-CoV-2, the virus that causes COVID-19, and raised no serious safety concerns in an early-stage clinical trial.
By Leigh MacMillan
October 24, 2019

Article examines need for genotyping after stenting

Genotyping can improve outcomes in patients who require anti-platelet therapy following stent placement to open narrowed or blocked coronary arteries and prevent a heart attack.
By Bill Snyder
October 9, 2019

Vanderbilt health policy expert explains TennCare block grant proposal

Tennessee has made an “opening bid” in its negotiations with the federal government about a block grant that could significantly change how TennCare functions for more than 1 million children and low-income individuals, and making sense of the complex proposal can be tricky.
By Jill Clendening
September 25, 2019

Study identifies targeted therapy’s cardiac risks

After a recent study showed that chronic lymphocytic leukemia patients who received ibrutinib as a frontline treatment had a 7% death rate, a new study offers a clearer picture on the reasons for the deaths.
By Tom Wilemon
September 19, 2019

All-in-one pill helps reduce blood pressure, cholesterol

A single pill containing low doses of three medications to treat high blood pressure and one to lower cholesterol reduced the estimated risk of cardiovascular disease by 25%, according to a VUMC study.
By Craig Boerner
August 14, 2019

All of Us Research Program Takes Aim at Precision Population Health

Scarcely a year after its national launch, the “All of Us” research program, which aims to accelerate the prevention and treatment of disease, has enrolled more than 230,000 research participants — more than a fifth of its recruitment goal of 1 million people. All
By Bill Snyder
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