Science Advances (journal)

February 7, 2024

VUMC study finds molecular switch key to repair of kidney damage

Researchers at Vanderbilt University Medical Center have identified Rac1, a molecular switch that regulates the actin cytoskeleton of epithelial cells in the collecting ducts, as a driver of post-obstructive kidney repair.

By Bill Snyder
January 30, 2024

3D brain mapping opens a window to the aging brain

By mapping brain activity in three dimensions, researchers at Vanderbilt University Medical Center have achieved a more detailed picture of how the brain changes with age.

By Bill Snyder
May 18, 2023

New view of mutations informs disease risk, treatment response

A transcontinental research effort led by scientists from Vanderbilt University Medical Center and the University of Michigan has upended some long-standing assumptions about mutations — how often they occur, what causes them and what they do.

By Bill Snyder
April 6, 2023

System repairs donor lungs for transplantation

A Vanderbilt team has discovered that donor lungs rejected for transplant can be repaired using cross-circulation with a xenogeneic host.

By Matt Batcheldor
November 3, 2022

Study explores possible drug target for neurological problems

A team at Case Western Reserve University and Vanderbilt University Medical Center has determined with atomic-level precision how two established drugs bind to and alter the conformation of a cell membrane transporter protein called NKCC1, shutting down its activity.

By Paul Govern
Insulin in vials
October 20, 2022

Aging beta cells hasten Type 2 diabetes

Vanderbilt investigators have found that aging induces chronic cellular stress in pancreatic beta cells, which could contribute to the development of diabetes as we age.

By Bill Snyder
December 16, 2021

Game theory points to new DNA data privacy solutions

Vanderbilt research is blazing a trail for the application of game theory to genomic and health data reidentification risk.
By Paul Govern
September 10, 2021

Caught in a web: study reveals that immune cells cooperate to trap and kill bacteria

Vanderbilt researchers have identified a new antibacterial mechanism that could inspire novel strategies for combating staph and other extracellular bacterial pathogens.
By Leigh MacMillan
July 8, 2020

New clues to lung-scarring disease may aid treatment

Scientists at Vanderbilt University Medical Center and the Translational Genomics Research Institute (TGen) in Phoenix, Arizona, have discovered previously unreported genetic and cellular changes that occur in the lungs of people with pulmonary fibrosis (PF).
By Bill Snyder
December 4, 2019

Genetic screen in worms reveals critical step in insulin synthesis

The identification of a protein important for insulin synthesis may hold clues for understanding the pathogenesis of diabetes.
By Leigh MacMillan
August 23, 2018

Clue to treating obesity found in body’s ‘rheostat’

Researchers at Vanderbilt University and the University of Michigan have discovered a critical factor in the rheostatic control of body weight by the brain.
By Bill Snyder
March 12, 2018

Long QT syndrome – revealed

Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders.
By Bill Snyder
August 17, 2017

Discovery sheds light on protein key to nerve cells’ myelin sheath

Genetic mutations in PMP22 (peripheral myelin protein 22) cause a variety of peripheral neuropathies, underscoring the importance of the protein to a healthy peripheral nervous system. But the precise function of PMP22, a major component of the myelin sheath that surrounds and insulates peripheral nerve cell axons, has been unclear.
By Leigh MacMillan
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