Science Advances (journal) Archive — Page 1 of 2

Roy Zent and graduate student Xinyu Dong stand together in a laboratory surrounded by research equipment and workbenches.
October 15, 2026

Cytoskeletal protein key to normal kidney development

Study shows that a cytoskeletal protein, alpha-parvin, regulates branching of the ureteric bud, which elongates to form the ureter connecting the kidneys to the bladder.

A giant tortoise walks across a grassy enclosure, facing the camera, with trees and fencing in the background.
October 7, 2026

An extremely old giant tortoise named Jonathan may hold the secret to a long, healthy life: Study

Jonathan’s secret involves entropy, the tendency of biological systems to become disordered over time.

Two women pose outdoors in front of an ornate stone building and arched doorway on a university campus. The woman on the left wears a blue sweater, and the woman on the right wears a black sleeveless top.
June 17, 2025

VUMC-led research a step closer to understanding, preventing asthma 

“Findings from this study indicate that children who develop wheezing have different airway characteristics early in life, even before they develop asthma,” said Tina Hartert, MD, MPH.

Illustration of two human kidneys shown in cross section, with internal structures and connecting blood vessels visible.
February 7, 2024

VUMC study finds molecular switch key to repair of kidney damage

Researchers at Vanderbilt University Medical Center have identified Rac1, a molecular switch that regulates the actin cytoskeleton of epithelial cells in the collecting ducts, as a driver of post-obstructive kidney repair.

Stylized glowing blue brain with pink and white points of light against a blue background.
January 30, 2024

3D brain mapping opens a window to the aging brain

By mapping brain activity in three dimensions, researchers at Vanderbilt University Medical Center have achieved a more detailed picture of how the brain changes with age.

Portrait of Alexander Bick, MD, PhD, wearing a white medical coat and dark blue tie against a dark background.
May 18, 2023

New view of mutations informs disease risk, treatment response

A transcontinental research effort led by scientists from Vanderbilt University Medical Center and the University of Michigan has upended some long-standing assumptions about mutations — how often they occur, what causes them and what they do.