The Journal of Immunology

March 28, 2024

VUMC team discovers antibodies that may prevent severe respiratory illness

Using a technique developed at Vanderbilt University Medical Center, researchers identified antibodies that are excellent leads as potential therapies for human parainfluenza virus 3, a leading cause of acute and potentially fatal respiratory illness.

By Bill Snyder
December 29, 2023

Glucose metabolism influences B cell function

Glucose metabolism influences the qualities of activated, mature B cells — white blood cells that are required for antibody-mediated immune responses, Vanderbilt researchers discovered.

By Leigh MacMillan
May 4, 2023

Tracking lung macrophages

A new technique will allow researchers to track subsets of immune cells that patrol and defend the lungs, to better understand the roles of these cells during lung inflammation, infection and injury.

By Leigh MacMillan
January 27, 2022

Impaired neutrophils in autoimmunity

Vanderbilt researchers help answer the question of why patients with autoimmune diseases like lupus are more susceptible to bacterial infections: their neutrophils have impaired antibacterial activity.

By Leigh MacMillan
3d rendering white blood cells with red blood cells
October 8, 2019

A new regulator of B cell development

New findings establish a role for the pro-inflammatory molecule IL-33 in the early development of antibody-producing B cells.

By Leigh MacMillan
red and blue boxing gloves
June 13, 2018

Novel infection fighter

A drug in use clinically to help make vaccines more effective may be a powerful new tool for fighting antibiotic-resistant infections.

By Meredith Jackson
April 20, 2018

Disease-fighting antibody production

New research links nutrient-responsive cellular signaling to the antibody-mediated immune response.
By Leigh MacMillan
April 19, 2017

Predicting the infection response

Vanderbilt investigators are probing the response to a bacterial toxin as a clinical assessment of immune function.
By Sanjay Mishra
February 8, 2017

Pathology of septic shock

The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection.
By Leigh MacMillan
September 14, 2016

Restore T cells to fight leukemia

Modulation of T cell metabolism thus may represent a new therapeutic avenue for leukemia patients.
By Bill Snyder
April 3, 2013

“Silent” B cells trigger autoimmunity

Immune cells that recognize self antigens (e.g. insulin), but are functionally silent, can trigger autoimmune diseases such as diabetes.
By Leigh MacMillan
March 1, 2013

Target for inflammatory bowel disease

The factor STAT6 appears to play a role in the pathogenesis of an inflammatory bowel disease, suggesting it may be a promising target for new treatments.
By Leigh MacMillan
June 28, 2012

Low oxygen could protect sick kidneys

Low oxygen – and the activation of factors that respond to this situation – may be protective in chronic kidney disease.
By Leigh MacMillan