Research

Vanderbilt neurologists have identified a protein modification that could be targeted to reduce neuronal excitability in epilepsy.

A drug used to treat and prevent HIV/AIDS is showing promise as a potential therapy for Alzheimer’s disease.

A computational method that uses hospital billing codes and electronic health records can identify genetic disease cases before clinical teams do.

Poorly functioning AMPARs have been linked to a wide range of neurological and psychiatric disorders including seizures, Alzheimer’s disease, major depression and autism spectrum disorder. Understanding how AMPARs are formed and operate is essential for the rational design of pharmacological compounds that, by tuning AMPAR activity up or down, could improve treatment of these conditions.

The identification of a protein important for insulin synthesis may hold clues for understanding the pathogenesis of diabetes.

To explore how fear becomes entrenched, VUMC researchers traveled down the precise neuronal pathways in the brains of mice that trigger fear responses, and which normally extinguish the behaviors once the danger has passed.