Research

Lisa Bastarache, MS, Josh Denny, MD, MS, and colleagues are helping researchers study associations among de-identified genotype data and electronic health records data. (photo by John Russell)
February 7, 2019

PheWAS Core helps researchers make sense of electronic health record data

Some biomedical researchers may be unsure about routine electronic health record (EHR) data and how useful it ultimately may prove for drawing meaningful, actionable associations that warrant changes to clinical practice and lead to improved clinical outcomes.

By Paul Govern
Vanderbilt Prize recipient Angelika Amon, PhD, center, poses for a photo with Jennifer Pietenpol, PhD, and Lawrence Marnett, PhD.
February 7, 2019

Vanderbilt Prize lecturer Amon driven to solve genetic mysteries

For much of her career, Angelika Amon, PhD, recipient of the 2018 Vanderbilt Prize in Biomedical Science, has pursued a mystery with life-or-death consequences.

By Bill Snyder
array of test tubes with pipette dropping fluid into one
January 31, 2019

Destructive ‘telegrams’ in asthma

Vanderbilt investigators have discovered that certain microRNAs — “telegram”-like signals — increase after the induction of allergic airway inflammation.

By Bill Snyder
January 31, 2019

In utero antibiotics and obesity risk

Maternal antibiotic use during pregnancy was not associated with childhood obesity at age 5, according a national study led by a Vanderbilt pediatrician.

By Leigh MacMillan
January 31, 2019

Designing antibodies to fight the flu

Vanderbilt investigators said their work shows that computational design can improve the ability of naturally occurring antibodies to recognize different flu strains and may hasten the development of more effective flu therapies and vaccines.

By Bill Snyder
January 31, 2019

Study explores genetic risk for suicide attempt

Using data from the UK Biobank and Vanderbilt’s BioVU, a new study in the journal Molecular Psychiatry finds that approximately 4 percent of suicide attempt risk is captured by genotype data.

By Paul Govern
January 31, 2019

New target for chronic kidney disease

Preventing the formation of secretory structures that promote scarring in the kidney could offer new therapeutic options for a disease that affects millions of people worldwide.
By Leigh MacMillan
January 31, 2019

Cell death pathway implicated in bone marrow failure

Vanderbilt investigators have linked a specific form of programmed cell death to myelodysplastic syndrome, a type of bone marrow failure.
By Leigh MacMillan
January 24, 2019

Vanderbilt Prize winner Amon to speak at Jan. 31 lecture

Angelika Amon, PhD, recipient of the 2018 Vanderbilt Prize in Biomedical Science, will deliver her Vanderbilt Prize lecture at 4 p.m. Thursday, Jan. 31, in 208 Light Hall.
By Bill Snyder
January 17, 2019

Signals from the “conveyor belt”

Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.
By Bill Snyder
January 17, 2019

Pain relievers a risk for C. diff?

A link between anti-inflammatory drugs such as ibuprofen and C. diff infection suggests caution against overusing such drugs in patients at high risk for infection.
By Leigh MacMillan
January 17, 2019

DNA’s on/off switch

DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.
By Bill Snyder
January 17, 2019

Building a pancreas

Vanderbilt investigators are defining the genetic programs that control the development of pancreatic beta cells — studies that could inform new cellular or regenerative therapies for diabetes.
By Leigh MacMillan
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